1350543-67-7 Usage
Uses
Used in Pharmaceutical Research:
(Z)-3-(6-fluoro-1H-indol-3-yl)acrylonitrile is used as a building block for the development of new pharmaceutical compounds due to its potential biological activities. Its unique structure allows for the creation of various functionalized molecules, which can be further explored for their therapeutic properties and potential applications in treating different medical conditions.
Used in Organic Synthesis:
In the field of organic synthesis, (Z)-3-(6-fluoro-1H-indol-3-yl)acrylonitrile serves as an important intermediate. Its reactivity and structural features make it a versatile starting material for the preparation of complex organic compounds, contributing to the advancement of chemical research and the development of novel materials.
Used in Chemical Intermediates Production:
(Z)-3-(6-fluoro-1H-indol-3-yl)acrylonitrile is also utilized as a key intermediate in the production of various chemical intermediates. These intermediates can be further processed or modified to create a wide range of chemical products, including those used in the pharmaceutical, agrochemical, and materials science industries.
Overall, (Z)-3-(6-fluoro-1H-indol-3-yl)acrylonitrile is a significant compound in the realms of organic chemistry and pharmaceutical research, with its applications spanning across multiple industries and research areas.
Check Digit Verification of cas no
The CAS Registry Mumber 1350543-67-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,0,5,4 and 3 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1350543-67:
(9*1)+(8*3)+(7*5)+(6*0)+(5*5)+(4*4)+(3*3)+(2*6)+(1*7)=137
137 % 10 = 7
So 1350543-67-7 is a valid CAS Registry Number.
1350543-67-7Relevant articles and documents
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators
Dolu?i?, Eduard,Larrieu, Pierre,Moineaux, Laurence,Stroobant, Vincent,Pilotte, Luc,Colau, Didier,Pochet, Lionel,Van Den Eynde, Beno?t,Masereel, Bernard,Wouters, Johan,Frédérick, Rapha?l
supporting information; experimental part, p. 5320 - 5334 (2011/10/02)
Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active area of research in drug development. Recently, our group has shown that tryptophan 2,3-dioxygenase (TDO), an unrelated hepatic enzyme also catalyzing the first step of tryptophan degradation, is also expressed in many tumors and that this expression prevents tumor rejection by locally depleting tryptophan. Herein, we report a structure-activity study on a series of 3-(2-(pyridyl)ethenyl)indoles. More than 70 novel derivatives were synthesized, and their TDO inhibitory potency was evaluated. The rationalization of the structure-activity relationships (SARs) revealed essential features to attain high TDO inhibition and notably a dense H-bond network mainly involving His55 and Thr254 residues. Our study led to the identification of a very promising compound (58) displaying good TDO inhibition (Ki = 5.5 μM), high selectivity, and good oral bioavailability. Indeed, 58 was chosen for preclinical evaluation.
