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1393466-87-9

(R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide is a complex organic compound with a unique chemical structure. It is characterized by its molecular composition, which includes various functional groups such as cyclopropyl, pyrimidinyl, pyrrolo, and fluorophenyl moieties. (R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide is of interest due to its potential applications in various fields, particularly in the pharmaceutical industry.

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  • 1393466-87-9 Structure

  • Basic information

    1. Product Name: (R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide
    2. Synonyms: N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo(2,3-b)pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide;PLX8394
    3. CAS NO:1393466-87-9
    4. Molecular Formula: C25H21F3N6O3S
    5. Molecular Weight: 542.5
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1393466-87-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: (R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide(1393466-87-9)
    11. EPA Substance Registry System: (R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide(1393466-87-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1393466-87-9(Hazardous Substances Data)

1393466-87-9 Usage

Uses

Used in Pharmaceutical Industry:
(R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide is used as a potential therapeutic agent for the treatment of KRAS G12C cancers. Its application is based on its ability to act as a KRAS G12C inhibitor, which is a mutation commonly found in various types of cancer. By targeting this specific mutation, the compound can potentially inhibit the growth and progression of cancer cells, offering a targeted approach to cancer treatment.
Additionally, (R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide is used as a BRAF inhibitor. BRAF mutations are also associated with various types of cancer, and by inhibiting this protein, the compound can potentially disrupt cancer cell signaling pathways, leading to the suppression of tumor growth.
Used in Combination Therapies:
In the field of oncology, (R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide is used in combination therapies, which involve the simultaneous use of multiple drugs to enhance the overall treatment efficacy. By combining (R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide with other cancer-fighting agents, such as Raf kinase inhibitors, a synergistic effect can be achieved, potentially leading to improved outcomes for patients with KRAS G12C cancers.

Check Digit Verification of cas no

The CAS Registry Mumber 1393466-87-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,3,4,6 and 6 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1393466-87:
(9*1)+(8*3)+(7*9)+(6*3)+(5*4)+(4*6)+(3*6)+(2*8)+(1*7)=199
199 % 10 = 9
So 1393466-87-9 is a valid CAS Registry Number.

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