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DIETHYL 2-HYDROXYMALONATE is a versatile chemical compound that is an ester derivative of malonic acid, featuring two ethyl groups attached to the malonate backbone. It is recognized for its capacity to participate in a range of chemical reactions such as ester hydrolysis and decarboxylation, which makes it a valuable building block in the synthesis of complex organic molecules. Additionally, it has been noted for its antioxidant and anti-inflammatory properties, and is currently under investigation for its potential therapeutic applications in medicine.

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  • 13937-08-1 Structure
  • Basic information

    1. Product Name: DIETHYL 2-HYDROXYMALONATE
    2. Synonyms: HYDROXYMALONIC ACID DIETHYL ESTER;DIETHYLHYDROXYMALONATE;DIETHYL 2-HYDROXYMALONATE;Diethylhydroxymalonate, min. 97 %;Propanedioic Acid, Hydroxy-, Diethyl Ester;Diethyl 2-hydroxypropane-1,3-dioate
    3. CAS NO:13937-08-1
    4. Molecular Formula: C7H12O5
    5. Molecular Weight: 176.17
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 13937-08-1.mol
  • Chemical Properties

    1. Melting Point: -2.5°C
    2. Boiling Point: 221°C (estimate)
    3. Flash Point: 87.7 °C
    4. Appearance: /
    5. Density: 1.1520
    6. Vapor Pressure: 0.0194mmHg at 25°C
    7. Refractive Index: 1.4400 (estimate)
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: DIETHYL 2-HYDROXYMALONATE(CAS DataBase Reference)
    11. NIST Chemistry Reference: DIETHYL 2-HYDROXYMALONATE(13937-08-1)
    12. EPA Substance Registry System: DIETHYL 2-HYDROXYMALONATE(13937-08-1)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 13937-08-1(Hazardous Substances Data)

13937-08-1 Usage

Uses

Used in Organic Synthesis:
DIETHYL 2-HYDROXYMALONATE is used as a building block for the synthesis of complex organic molecules due to its ability to undergo various chemical reactions, including ester hydrolysis and decarboxylation.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, DIETHYL 2-HYDROXYMALONATE is utilized as a key intermediate in the production of various drugs, leveraging its reactivity and functional group chemistry to create medicinal compounds.
Used in Antioxidant and Anti-Inflammatory Applications:
DIETHYL 2-HYDROXYMALONATE is being studied for its potential therapeutic applications, particularly for its antioxidant and anti-inflammatory properties, which could be beneficial in the treatment of various medical conditions.
Used in Research and Development:
In the field of research, DIETHYL 2-HYDROXYMALONATE serves as a subject of study for understanding its chemical properties and exploring its potential uses in new therapeutic areas or as a component in novel chemical processes.

Check Digit Verification of cas no

The CAS Registry Mumber 13937-08-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,3 and 7 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 13937-08:
(7*1)+(6*3)+(5*9)+(4*3)+(3*7)+(2*0)+(1*8)=111
111 % 10 = 1
So 13937-08-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H12O5/c1-3-11-6(9)5(8)7(10)12-4-2/h5,8H,3-4H2,1-2H3

13937-08-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name diethyl 2-hydroxypropanedioate

1.2 Other means of identification

Product number -
Other names diethyl hydroxymalonate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13937-08-1 SDS

13937-08-1Relevant articles and documents

Photoredox-Enabled Synthesis of β-Substituted Pyrroles from Pyrrolidines

An, Xiao-De,Yang, Shuo,Qiu, Bin,Yang, Ting-Ting,Li, Xian-Jiang,Xiao, Jian

, p. 9558 - 9565 (2020)

The merger of photoredox-initiated enamine-imine tautomerization and nucleophilic addition processes to access β-substituted pyrroles from pyrrolidines has been achieved. The significant advantage of this method is suppressing the Friedel-Crafts reaction,

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