1446282-18-3 Usage
Uses
Used in Chemical Biology and Medicinal Chemistry:
Amino-PEG5-t-butyl ester is used as a building block for the synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation.
Used in Bioconjugation:
Amino-PEG5-t-butyl ester is used as a crosslinker for bioconjugation, facilitating the attachment of biomolecules to other molecules or surfaces.
Used in Drug Delivery Systems:
Amino-PEG5-t-butyl ester is used as a component in the design of drug delivery systems, such as antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC molecules) for targeted protein degradation.
Used in the Synthesis of Conjugates:
Amino-PEG5-t-butyl ester is used as a linker in the synthesis of conjugates, enhancing the solubility and stability of the final product in biological applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1446282-18-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,6,2,8 and 2 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1446282-18:
(9*1)+(8*4)+(7*4)+(6*6)+(5*2)+(4*8)+(3*2)+(2*1)+(1*8)=163
163 % 10 = 3
So 1446282-18-3 is a valid CAS Registry Number.
1446282-18-3Relevant articles and documents
Preparation method of amino polyethylene glycol propionic acid
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Paragraph 0095; 0100, (2019/01/14)
The invention relates to the field of organic synthesis, in particular to a preparation method of amino polyethylene glycol propionic acid. The preparation method comprises the steps that catalytic hydrogenation is carried out on dibenzyl amino polyethylene glycol tert-butyl propionate shown in formula I-2 to obtain amino polyethylene glycol tert-butyl propionate shown in formula I-3; (2) the amino polyethylene glycol tert-butyl propionate shown in formula I-3 is hydrolyzed under the acidic condition to obtain amino polyethylene glycol propionic acid shown in formula I. The preparation methodof the amino polyethylene glycol propionic acid has the advantages that the defects in the prior art that the yield is low, the dangerousness is high, and the enlargement of production is difficult are overcome, the reaction conditions are mild, the operation is simple, an intermediate does not to be purified, the next reaction can be directly carried out, the whole yield reaches up to 87-92%, thepurity of end products reaches up to 97-99.5%, and a safe and efficient synthetic route is provided for the preparation of amino polyethylene glycol propionic acid.
