145071-72-3 Usage
Uses
Used in Pharmaceutical Industry:
(4-aminophenyl)cyclopentylmethane is used as a building block for the synthesis of complex organic molecules, contributing to the development of new pharmaceuticals and organic compounds. Its unique structure allows for various pharmacological properties, which can be harnessed to create innovative drugs and therapies.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (4-aminophenyl)cyclopentylmethane is used as a key component in the design and synthesis of novel compounds with potential therapeutic applications. Its versatility and unique structure make it an attractive candidate for further research and development, with the aim of discovering new drugs and treatments for various medical conditions.
Used in Organic Synthesis:
(4-aminophenyl)cyclopentylmethane is also utilized in organic synthesis, where it serves as a starting material or intermediate for the creation of a wide range of organic compounds. Its unique structure and functional groups make it a valuable asset in the synthesis of complex molecules, potentially leading to new discoveries and advancements in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 145071-72-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,0,7 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 145071-72:
(8*1)+(7*4)+(6*5)+(5*0)+(4*7)+(3*1)+(2*7)+(1*2)=113
113 % 10 = 3
So 145071-72-3 is a valid CAS Registry Number.
145071-72-3Relevant articles and documents
Synthesis and evaluation of 4-alkylanilines as mammary tumor inhibiting aromatase inhibitors
Hartmann,Batzl
, p. 537 - 544 (2007/10/02)
The 4-alkylanilines 1-20 were synthesized to elucidate the importance of the glutarimide moiety for the aromatase inhibiting activity of aminoglutethimide [3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione, AG], the only non-steroidal aromatase inhibitor which is commercially available at present. The most interesting compounds were the (4-aminophenyl)cycloalkanes 4-6 (4, c-pentyl; 5, c-hexyl; 6, c-heptyl) and the 1-alkyl-1-(4-aminophenyl)cyclohexanes 1-3 (1, CH3; 2, C2H5; 3, n-C3H7). Derivatives 1-6 are stronger inhibitors of human placental aromatase than AG exhibiting relative potencies from 1.5 to 2.7 (AG≡1). For selectivity of action, the inhibition of desmolase (cholesterol side chain cleavage enzyme) was determined. Compounds 1-3 showed an inhibition comparable to AG, whereas compounds 4-6 exhibited no effect on desmolase. Being more potent and selective aromatase inhibitors in vitro, compounds 4-6, however, were not superior to AG in vivo, when the reduction of plasma estradiol concentration and the tumor inhibiting activity (PMSG-primed SD rats and DMBA-induced mammary carcinoma of the SD rat, postmenopausal model) were concerned.
