FMoc-PNA-C(Bhoc)-OH is a peptide nucleic acid (PNA) derivative used in medicinal chemistry and molecular biology. It features a PNA backbone with a fluorenylmethyloxycarbonyl (Fmoc) protecting group at the N-terminus and a 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) activated carboxylic acid at the C-terminus. The base, N-(9H-fluoren-9-ylmethoxycarbonyl)-N-(2-iodoethoxy-carbonyl)glycine ((9H-fluoren-9-ylmethoxycarbonyl)glycine, abbreviated as Bhoc), is incorporated for stability, making it a versatile compound for the synthesis of PNA and its derivatives.
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Basic information
- Product Name: FMoc-PNA-C(Bhoc)-OH
- Synonyms: FMoc-PNA-C(Bhoc)-OH;N-[[4-[[(Diphenylmethoxy)carbonyl]amino]-2-oxo-1(2H)-pyrimidinyl]acetyl]-N-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]glycine
- CAS NO:186046-81-1
- Molecular Formula: C39H35N5O8
- Molecular Weight: 701.7239
- EINECS: N/A
- Product Categories: N/A
- Mol File: 186046-81-1.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: 1.34±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 3.14±0.10(Predicted)
- CAS DataBase Reference: FMoc-PNA-C(Bhoc)-OH(CAS DataBase Reference)
- NIST Chemistry Reference: FMoc-PNA-C(Bhoc)-OH(186046-81-1)
- EPA Substance Registry System: FMoc-PNA-C(Bhoc)-OH(186046-81-1)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 186046-81-1(Hazardous Substances Data)
186046-81-1 Usage
Uses
Used in Pharmaceutical Industry:FMoc-PNA-C(Bhoc)-OH is used as a building block for the synthesis of peptide nucleic acids and their derivatives. It is utilized for the development of gene therapy, antisense therapy, and diagnostics applications. FMoc-PNA-C(Bhoc)-OH's unique structure allows for the creation of stable and specific PNA molecules that can target and modulate gene expression, offering potential therapeutic benefits in various diseases.
Used in Molecular Biology Research:
In molecular biology, FMoc-PNA-C(Bhoc)-OH serves as a key component in the synthesis of PNA probes and conjugates. These PNA molecules can be used for various research applications, such as DNA and RNA recognition, hybridization studies, and the development of biosensors. FMoc-PNA-C(Bhoc)-OH's versatility and stability make it an essential tool for advancing molecular biology research and understanding the fundamental mechanisms of gene regulation and expression.
Used in Diagnostics:
FMoc-PNA-C(Bhoc)-OH is used as a component in the development of diagnostic tools, such as PNA-based probes for detecting specific nucleic acid sequences. These probes can be employed in various diagnostic assays, including polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH), and microarrays. The high specificity and stability of PNA probes make them valuable for accurate and reliable detection of genetic markers and disease-associated mutations.
Check Digit Verification of cas no
The CAS Registry Mumber 186046-81-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,0,4 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.Calculate Digit Verification of CAS Registry Number 186046-81:
(8*1)+(7*8)+(6*6)+(5*0)+(4*4)+(3*6)+(2*8)+(1*1)=151
151 % 10 = 1
So 186046-81-1 is a valid CAS Registry Number.
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FMoc-PNA-C(Bhoc)-OH
