2172908-07-3Relevant articles and documents
Gamma-alkenyl substituted butylene lactone or butylene lactam compound and asymmetric synthesis method thereof and ligand
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Paragraph 0167-0170, (2019/12/15)
The invention discloses an asymmetric synthesis method of a gamma-alkenyl substituted butylene lactone or butylene lactam compound. The method uses cheap nickel to catalyze a [3+2] asymmetric cycloaddition reaction of a cyclopropenone compound and an alph
Enantioselective Palladium-Catalyzed Oxidative Cascade Cyclization of Aliphatic Alkenyl Amides
Du, Wei,Gu, Qiangshuai,Li, Yang,Lin, Zhenyang,Yang, Dan
supporting information, p. 316 - 319 (2017/04/21)
The catalyst system of Pd(TFA)2/(S,S)-diPh-pyrox is reported to promote the highly efficient enantioselective oxidative cascade cyclization of alkene-tethered aliphatic acrylamides under mild aerobic conditions. A series of pyrrolizidine derivatives have been synthesized in good yield and excellent enantioselectivity. Deuterium-labeling experiments have revealed that the reaction proceeded through an anti-aminopalladation (anti-AP) pathway with high selectivity. The transition states for the anti-AP step have been calculated to account for the observed enantioselectivity.
