2172947-67-8Relevant articles and documents
Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors
Harrison, David,Boutard, Nicolas,Brzozka, Krzysztof,Bugaj, Marta,Chmielewski, Stefan,Cierpich, Anna,Doedens, John R.,Fabritius, Charles-Henry R.Y.,Gabel, Christopher A.,Galezowski, Michal,Kowalczyk, Piotr,Levenets, Oleksandr,Mroczkowska, Magdalena,Palica, Katarzyna,Porter, Roderick A.,Schultz, David,Sowinska, Marta,Topolnicki, Grzegorz,Urbanski, Piotr,Woyciechowski, Jakub,Watt, Alan P.
supporting information, (2020/10/02)
The NLRP3 inflammasome is a component of the innate immune system involved in the production of proinflammatory cytokines. Aberrant activation by a wide range of exogenous and endogenous signals can lead to chronic, low-grade inflammation. It has attracted a great deal of interest as a drug target due to the association with diseases of large unmet medical need such as Alzheimer's disease, Parkinson's disease, arthritis, and cancer. To date, no drugs specifically targeting inhibition of the NLRP3 inflammasome have been approved. In this work, we used the known NLRP3 inflammasome inhibitor CP-456,773 (aka CRID3 or MCC 950) as our starting point and undertook a Structure-Activity Relationship (SAR) analysis and subsequent scaffold-hopping exercise. This resulted in the rational design of a series of novel ester-substituted urea compounds that are highly potent and selective NLRP3 inflammasome inhibitors, as exemplified by compounds 44 and 45. It is hypothesized that the ester moiety acts as a highly permeable delivery vehicle and is subsequently hydrolyzed to the carboxylic acid active species by carboxylesterase enzymes. These molecules are greatly differentiated from the state-of-the-art and offer potential in the treatment of NLRP3-driven diseases, particularly where tissue penetration is required.
SULFONYL UREA DERIVATIVES AND THEIR USE IN THE CONTROL OF INTERLEUKIN-1 ACTIVITY
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Page/Page column 66; 67, (2018/02/17)
The present invention relates to compounds of Formula (I) and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases.
