2361948-73-2 Usage
Uses
Used in Coordination Chemistry:
(4-amino-2-methylphenyl)dimethylphosphine oxide is used as a ligand for forming coordination complexes with transition metals, which is crucial in various chemical reactions and applications.
Used in Organic Synthesis:
(4-amino-2-methylphenyl)dimethylphosphine oxide serves as a valuable intermediate in the synthesis of a wide range of organic molecules, contributing to the diversity of chemical products.
Used as a Flame Retardant in Polymers:
(4-amino-2-methylphenyl)dimethylphosphine oxide is utilized as an additive in the polymer industry to enhance the flame retardancy of materials, improving their safety characteristics.
Used in Medicinal Chemistry:
Due to its ability to bind to metal ions and its demonstrated biological activity, (4-amino-2-methylphenyl)dimethylphosphine oxide holds potential in the development of new pharmaceuticals and therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 2361948-73-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,3,6,1,9,4 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2361948-73:
(9*2)+(8*3)+(7*6)+(6*1)+(5*9)+(4*4)+(3*8)+(2*7)+(1*3)=192
192 % 10 = 2
So 2361948-73-2 is a valid CAS Registry Number.
2361948-73-2Relevant articles and documents
Phosphine Oxides (-POMe2) for Medicinal Chemistry: Synthesis, Properties, and Applications
Stambirskyi, Maksym V.,Kostiuk, Tetiana,Sirobaba, Serhii I.,Rudnichenko, Alexander,Titikaiev, Dmytro L.,Dmytriv, Yurii V.,Kuznietsova, Halyna,Pishel, Iryna,Borysko, Petro,Mykhailiuk, Pavel K.
, p. 12783 - 12801 (2021/09/18)
A general practical approach to hetero(aromatic) and aliphatic P(O)Me2-substituted derivatives is elaborated. The key synthetic step was a [Pd]-mediated C-P coupling of (hetero)aryl bromides/iodides with HP(O)Me2. The P(O)Me2 substituent was shown to dramatically increase solubility and decrease lipophilicity of organic compounds. This tactic was used to improve the solubility of the antihypertensive drug prazosin without affecting its biological profile.
