3,4-Pyrrolidinediol, 2-(hydroxymethyl)-5-(4-hydroxyphenyl)-, (2S,3S,4S,5S)- (9CI)

10.1016/j.tetlet.2011.07.035

The research presents a stereoselective synthesis of the naturally occurring pyrrolidine alkaloid, (+)-radicamine B, which possesses significant biological properties. The synthesis involves 13 steps, starting from commercially available p-hydroxybenzaldehyde, with an overall yield of 9.75%. Key reactions include Sharpless asymmetric epoxidation and Horner–Wadsworth–Emmons (HWE) olefination. Reactants used throughout the synthesis include p-hydroxybenzaldehyde, tosyl chloride, (+)-DET, NaN3, PPh3, Boc anhydride, benzaldehyde dimethylacetal, DIBAL-H, IBX, (OEt)2PO(CH2COOEt), and (+)-DIPT, among others. Analytical techniques employed to characterize the intermediates and final product included 1H NMR, 13C NMR, Mass spectrometry, and IR spectroscopy, with enantioselectivity determined by chiral HPLC. The study also discusses the biological significance of radicamine B and the challenges in its asymmetric synthesis, highlighting the efficiency and linearity of their developed synthetic protocol.