The research presents a ruthenium(II)-catalyzed intramolecular [2+2+2] cyclization of allene-yne-enes to construct fused-tricyclic skeletons. The reaction involves the use of a [Cp*RuCl(cod)] catalyst with various substrates to form tricyclic compounds in a stereoselective manner. The study investigates the effects of different substituents on the allene and alkene moieties, as well as the linker structure, on the yield and stereochemistry of the products. Experiments were conducted with various allene-yne-ene substrates, and the yields and stereochemistry of the resulting tricyclic compounds were analyzed. Techniques such as X-ray crystallographic analysis and NOESY experiments were employed to determine the stereochemistry of the products. The reaction mechanism is proposed to involve the formation of a ruthenacyclopentene intermediate, followed by insertion of the unsaturated bond and reductive elimination to afford the tricyclic compounds.
15181-46-1
120-20-7
64443-05-6
756-79-6
616-52-4
589-21-9
120-93-4
453-13-4
64-20-0
57001-28-2