The study focuses on the synthesis and characterization of novel aminobenzylcantharidinimides and related imides using proton NMR spectra. Researchers reacted various acidic anhydrides, including cantharidin, with aminobenzylamines and triethylamine to produce a series of imides with yields ranging from 35% to 87%. These compounds were evaluated for their effects on nitric oxide (NO) induction, and the results showed that para-aminobenzylic imides were more effective in inhibiting NO synthesis compared to their ortho and meta counterparts. The most potent compound, 3fp, demonstrated 35% inhibition of inducible NO synthase (iNOS). The findings provide insights into the structure-activity relationships of these compounds and their potential as therapeutic agents.
