The study explores the application of [2,2]paracyclophane-based N,O-ligands in the asymmetric addition of alkenylzinc reagents to aldehydes, leading to the formation of chiral allyl alcohols. These compounds are important intermediates in various organic reactions. The research details the development of a method to generate alkenylzinc species through transmetalation using different reagents, which allows for fine-tuning the steric bulk and selectivity of the reaction. The study reports high enantioselectivities, especially for challenging substrates such as α-branched aliphatic aldehydes, and demonstrates the significant impact of the transmetalation agent on catalytic efficiency.
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