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603300-96-5

Furo[3,2-c]pyridine, 7-bromo- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 603300-96-5 Structure

  • Basic information

    1. Product Name: Furo[3,2-c]pyridine, 7-bromo-
    2. Synonyms: Furo[3,2-c]pyridine, 7-bromo-;7-bromofuro[3,2-c]pyridine
    3. CAS NO:603300-96-5
    4. Molecular Formula: C7H4BrNO
    5. Molecular Weight: 198.01676
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 603300-96-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 248.6±20.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.710±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 2.15±0.40(Predicted)
    10. CAS DataBase Reference: Furo[3,2-c]pyridine, 7-bromo-(CAS DataBase Reference)
    11. NIST Chemistry Reference: Furo[3,2-c]pyridine, 7-bromo-(603300-96-5)
    12. EPA Substance Registry System: Furo[3,2-c]pyridine, 7-bromo-(603300-96-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 603300-96-5(Hazardous Substances Data)

603300-96-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 603300-96-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,3,3,0 and 0 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 603300-96:
(8*6)+(7*0)+(6*3)+(5*3)+(4*0)+(3*0)+(2*9)+(1*6)=105
105 % 10 = 5
So 603300-96-5 is a valid CAS Registry Number.

603300-96-5Relevant articles and documents

Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases

Steinig, Arno G.,Li, An-Hu,Wang, Jing,Chen, Xin,Dong, Hanqing,Ferraro, Caterina,Jin, Meizhong,Kadalbajoo, Mridula,Kleinberg, Andrew,Stolz, Kathryn M.,Tavares-Greco, Paula A.,Wang, Ti,Albertella, Mark R.,Peng, Yue,Crew, Linda,Kahler, Jennifer,Kan, Julie,Schulz, Ryan,Cooke, Andy,Bittner, Mark,Turton, Roy W.,Franklin, Maryland,Gokhale, Prafulla,Landfair, Darla,Mantis, Christine,Workman, Jen,Wild, Robert,Pachter, Jonathan,Epstein, David,Mulvihill, Mark J.

, p. 4381 - 4387 (2013/07/26)

A series of novel 6-aminofuro[3,2-c]pyridines as kinase inhibitors is described, most notably, OSI-296 (6). We discuss our exploration of structure-activity relationships and optimization leading to OSI-296 and disclose its pharmacological activity against cMET and RON in cellular assays. OSI-296 is a potent and selective inhibitor of cMET and RON kinases that shows in vivo efficacy in tumor xenografts models upon oral dosing and is well tolerated.

The development of potent and selective bisarylmaleimide GSK3 inhibitors

Engler, Thomas A.,Malhotra, Sushant,Burkholder, Timothy P.,Henry, James R.,Mendel, David,Porter, Warren J.,Furness, Kelly,Diefenbacher, Clive,Marquart, Angela,Reel, Jon K.,Li, Yihong,Clayton, Joshua,Cunningham, Brian,McLean, Johnathan,O'Toole, John C.,Brozinick, Joseph,Hawkins, Eric,Misener, Elizabeth,Briere, Daniel,Brier, Richard A.,Wagner, Jill R.,Campbell, Robert M.,Anderson, Bryan D.,Vaughn, Renee,Bennett, Donald B.,Meier, Timothy I.,Cook, James A.

, p. 899 - 903 (2007/10/03)

Many 3-aryl-4-(1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indol-7-yl) maleimides exhibit potent GSK3 inhibitory activity (50), although few show significant selectivity (>100 ×) versus CDK2, CDK4, or PKCβII. However, combining 3-(imidazo[1,2-a]pyridin-3-yl), 3-(pyrazolo[1,5-a]pyridin-3-yl) or aza-analogs with a 4-(2-acyl-(1,2,3,4- tetrahydro[1,4]diazepino[6,7,1-hi]indol -7-yl)) group on the maleimide resulted in very potent inhibitors of GSK3 (≤5 nM) with >160 to >10,000-fold selectivity versus CDK2/4 and PKCβII. These compounds also inhibited tau phosphorylation in cells and were effective in lowering plasma glucose in a rat model of type 2 diabetes (ZDF rat).

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