The research presents a study on the Chlorotrimethylsilane-Mediated Friedl?nder Synthesis of 2-(a-Chloroalkyl)quinoline Derivatives, which are significant in medicinal chemistry for their use in synthesizing potential analgesics, anti-inflammatories, and other pharmaceuticals. The researchers explored a novel approach using chlorotrimethylsilane (TMSCl) as a catalyst and water scavenger in the Friedl?nder reaction, extending the scope of the reaction to include a-chloroketones. The study involved the condensation of 2-aminoacetophenone and 2-aminobenzophenone with ethyl 4-chloro-3-oxobutanoate, as well as reactions with 1,3-dichloroacetone and 2-chlorocyclohexanone under controlled conditions. The products were analyzed using 1H and 13C NMR spectroscopy, and the yields were compared to those from traditional procedures, showing significant improvements. The simplicity and high yield of the method make it a valuable tool for the synthesis of these important compounds.
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