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915720-71-7

(S)-tert-Butyl (1-(5-bromopyridin-2-yl)ethyl)carbamate is a carbamate derivative chemical compound characterized by the presence of a tert-butyl group, a carbamate group, and a 5-bromopyridin-2-yl group. It is utilized in various fields, particularly in organic synthesis and pharmaceutical research, where its unique molecular structure and interactions with other chemicals contribute to its potential applications.

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  • 915720-71-7 Structure

  • Basic information

    1. Product Name: (S)-tert-Butyl (1-(5-bromopyridin-2-yl)ethyl)carbamate
    2. Synonyms: (S)-tert-Butyl (1-(5-bromopyridin-2-yl)ethyl)carbamate
    3. CAS NO:915720-71-7
    4. Molecular Formula: C12H17BrN2O2
    5. Molecular Weight: 301.17958
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 915720-71-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: (S)-tert-Butyl (1-(5-bromopyridin-2-yl)ethyl)carbamate(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-tert-Butyl (1-(5-bromopyridin-2-yl)ethyl)carbamate(915720-71-7)
    11. EPA Substance Registry System: (S)-tert-Butyl (1-(5-bromopyridin-2-yl)ethyl)carbamate(915720-71-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 915720-71-7(Hazardous Substances Data)

915720-71-7 Usage

Uses

Used in Organic Synthesis:
(S)-tert-Butyl (1-(5-bromopyridin-2-yl)ethyl)carbamate is used as a synthetic intermediate for the creation of more complex organic molecules. Its unique structure allows it to participate in various chemical reactions, facilitating the synthesis of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (S)-tert-Butyl (1-(5-bromopyridin-2-yl)ethyl)carbamate is used as a research compound for the development of new drugs. Its molecular properties may contribute to the discovery of novel therapeutic agents, particularly in the areas of medicinal chemistry and drug design.
Used in Agrochemical Development:
(S)-tert-Butyl (1-(5-bromopyridin-2-yl)ethyl)carbamate may also have potential applications in the agrochemical sector. Its chemical properties could be harnessed in the development of new pesticides or other agricultural chemicals, contributing to more effective and targeted crop protection strategies.

Check Digit Verification of cas no

The CAS Registry Mumber 915720-71-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,5,7,2 and 0 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 915720-71:
(8*9)+(7*1)+(6*5)+(5*7)+(4*2)+(3*0)+(2*7)+(1*1)=167
167 % 10 = 7
So 915720-71-7 is a valid CAS Registry Number.

915720-71-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-tert-butyl (1-(5-bromopyridin-2-yl)ethyl)carbamate

1.2 Other means of identification

Product number -
Other names (S)-tert-butyl-1-(5-bromopyridin-2-yl)ethylcarbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:915720-71-7 SDS

915720-71-7Relevant articles and documents

DIMERIC OR POLYMERIC FORM OF MUTANT IDH INHIBITOR

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Paragraph 0144; 0159-0162, (2022/03/22)

The present invention provides a mutant IDH inhibitor in dimeric or multimeric form. Specifically, the present invention provides a compound of formula I, ????????Da-Wa-L-Wb-Db?????(I) or a pharmaceutically acceptable salt thereof. The compound of the present invention has excellent inhibitory activity against mutant IDH1.

Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor

Cho, Young Shin,Levell, Julian R.,Liu, Gang,Caferro, Thomas,Sutton, James,Shafer, Cynthia M.,Costales, Abran,Manning, James R.,Zhao, Qian,Sendzik, Martin,Shultz, Michael,Chenail, Gregg,Dooley, Julia,Villalba, Brian,Farsidjani, Ali,Chen, Jinyun,Kulathila, Raviraj,Xie, Xiaoling,Dodd, Stephanie,Gould, Ty,Liang, Guiqing,Heimbach, Tycho,Slocum, Kelly,Firestone, Brant,Pu, Minying,Pagliarini, Raymond,Growney, Joseph D.

supporting information, p. 1116 - 1121 (2017/10/18)

Inhibition of mutant IDH1 is being evaluated clinically as a promising treatment option for various cancers with hotspot mutation at Arg132. Having identified an allosteric, induced pocket of IDH1R132H, we have explored 3-pyrimidin-4-yl-oxazolidin-2-ones as mutant IDH1 inhibitors for in vivo modulation of 2-HG production and potential brain penetration. We report here optimization efforts toward the identification of clinical candidate IDH305 (13), a potent and selective mutant IDH1 inhibitor that has demonstrated brain exposure in rodents. Preclinical characterization of this compound exhibited in vivo correlation of 2-HG reduction and efficacy in a patient-derived IDH1 mutant xenograft tumor model. IDH305 (13) has progressed into human clinical trials for the treatment of cancers with IDH1 mutation.

3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH

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Page/Page column 69; 70, (2014/09/29)

The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are described herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant I DH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH

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Page/Page column 85, (2014/09/29)

The invention is directed to a formula (I), or a pharmamceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

CHEMICAL COMPOUNDS

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, (2010/11/25)

This invention relates to novel compounds having the formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.

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