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CAS

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923032-59-1

1-Allylcyclopropane-1-sulfonyl chloride is a chemical compound that functions as a MEK inhibitor. It is characterized by its unique structure, which includes an allyl group attached to a cyclopropane ring with a sulfonyl chloride group. 1-Allylcyclopropane-1-sulfonyl chloride has the potential to modulate cellular signaling pathways and exhibit inhibitory effects on abnormal cell proliferation.

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  • 923032-59-1 Structure

  • Basic information

    1. Product Name: 1-Allylcyclopropane-1-sulfonyl chloride
    2. Synonyms: 1-Allylcyclopropanesulfonyl chloride;1-Allylcyclopropane-1-sulfonyl chloride;1-(2-Propen-1-yl)cyclopropanesulfonyl Chloride;1-(prop-2-en-1-yl)cyclopropane-1-sulfonyl chloride
    3. CAS NO:923032-59-1
    4. Molecular Formula: C6H9ClO2S
    5. Molecular Weight: 180.65
    6. EINECS: N/A
    7. Product Categories: sulfonyl compound;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfonyl Chlorides
    8. Mol File: 923032-59-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 229.2 °C at 760 mmHg
    3. Flash Point: 92.4 °C
    4. Appearance: yellow oil
    5. Density: 1.32 g/cm3
    6. Refractive Index: 1.515
    7. Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
    8. Solubility: Chlroform
    9. CAS DataBase Reference: 1-Allylcyclopropane-1-sulfonyl chloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-Allylcyclopropane-1-sulfonyl chloride(923032-59-1)
    11. EPA Substance Registry System: 1-Allylcyclopropane-1-sulfonyl chloride(923032-59-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 923032-59-1(Hazardous Substances Data)

923032-59-1 Usage

Uses

Used in Pharmaceutical Industry:
1-Allylcyclopropane-1-sulfonyl chloride is used as a MEK inhibitor for its potential role in the treatment of cancer and other hyperproliferative diseases. As a MEK inhibitor, it can help regulate the MAPK/ERK signaling pathway, which is often dysregulated in cancer cells, leading to uncontrolled cell growth and proliferation. By inhibiting MEK, this compound may contribute to the suppression of tumor growth and the management of various cancer types.
Additionally, 1-Allylcyclopropane-1-sulfonyl chloride may also be utilized in research settings to study the mechanisms of cell proliferation and the effectiveness of MEK inhibition in different biological contexts. This can aid in the development of novel therapeutic strategies and the identification of potential drug candidates for the treatment of various diseases characterized by abnormal cell proliferation.

Check Digit Verification of cas no

The CAS Registry Mumber 923032-59-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,3,0,3 and 2 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 923032-59:
(8*9)+(7*2)+(6*3)+(5*0)+(4*3)+(3*2)+(2*5)+(1*9)=141
141 % 10 = 1
So 923032-59-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H9ClO2S/c1-2-3-6(4-5-6)10(7,8)9/h2H,1,3-5H2

923032-59-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Allylcyclopropane-1-Sulfonyl Chloride

1.2 Other means of identification

Product number -
Other names 1-Allylcyclopropane-1-sulfonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:923032-59-1 SDS

923032-59-1Downstream Products

923032-59-1Relevant articles and documents

BIOMARKERS FOR DETERMINING EFFECTIVE RESPONSE OF TREATMENTS OF HEPATOCELLULAR CARCINOMA (HCC) PATIENTS

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, (2014/01/07)

This invention is directed to the use of one or more biomarkers defined as KRAS or NRAS gene for predicting the pharmaceutical efficacy or clinical response of MEK protein kinase inhibitor and/or Sorafenib or Regorafenib to be administred to a Hepatocellu

COMBINATIONS OF MEK INHIBITORS AND RAF KINASE INHIBITORS AND USES THEREOF

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, (2012/06/16)

This invention concerns combinations of inhibitors of MEK, Raf protein kinases, and other kinases including VEGFR1-3 and PDGFR-β. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer and other hyperproliferative disorders.

NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMIDES AS MEK INHIBITORS

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Page/Page column 56, (2010/12/31)

The invention provides novel substituted 6-arylamino pyridone sulfonamides and 6 arylamino pyrazinone sulfonamides represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans

N-(ARYLAMINO)-SULFONAMIDE INHIBITORS OF MEK

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Page/Page column 52, (2008/06/13)

This invention concerns N-(2-arylamino) aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.

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