92901-20-7Relevant articles and documents
A simple route to β-aminomethylketones
Zawadzki, Stefan,Zwierzak, Andrzej
, p. 8505 - 8506 (2004)
A simple procedure leading to β-aminomethylketones has been developed. The procedure involves base-catalyzed Michael-type addition of sodium t-butyl acetoacetate to N-Boc imines generated in situ followed by hydrolysis and decarboxylation of the adducts.
Intermolecular mono-and dihydroamination of activated alkenes using a recoverable gold catalyst
Medina, Florian,Michon, Christophe,Agbossou-Niedercorn, Francine
supporting information, p. 6218 - 6227 (2013/01/15)
A combination of gold chloride organometallic complex and a silver salt was used to catalyze intermolecular hydroamination of activated alkenes, i.e aza-Michael reactions. The gold-catalyzed reactions of activated alkenes with nitrogen substrates were investigated and found to afford various mono-and dihydroamination products, the latter being rare and original. After flash chromatography, gold NHC catalyst could be recovered as a gold hydroxide NHC complex. When combined with a silver salt, the gold complex lead again to an active hydroamination catalyst.
Synthesis of novel 2-aminothiophene-3-carboxylates by variations of the Gewald reaction
Buchstaller,Siebert,Lyssy,Frank,Duran,Gottschlich,Noe
, p. 279 - 293 (2007/10/03)
The synthesis of the title compounds through variations of the Gewald reaction is presented. Knoevenagel condensation of methylketone derivatives with methyl cyanoacetate and subsequent treatment of the α,β-unsaturated nitriles with sulfur and amine resul
Comparison of the hypolipidemic activity of cyclic vs. acyclic imides
Voorstad,Chapman,Cocolas,Wyrick,Hall
, p. 9 - 12 (2007/10/02)
Two series of nitrogen-substituted cyclic and acyclic imides were examined for hypolipidemic activity in mice after dosing for 16 days at a dose of 20 mg/kg per day. The hypolipidemic activity of the unsubstituted, N-butyl, N-3-oxobutyl, and N-2-carboxyethyl derivatives of diacetimide and succinimide were compared as well as the unsubstituted and N-substituted dibenzimide and diphenimide. It was shown that an imide functionally incorporated into a ring was not necessary for hypocholesterolemic activity. Good hypocholesterolemic activity was observed in both series of acyclic and cyclic imides. However, a cyclic imido structure was a necessary requirement for good hypotriglyceridemic activity. A decrease in hypotriglyceridemic activity was noted when comparing the cyclic imides to their respective acyclic congeners.
