Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, also known as Propargyl-PEG3-CH2CO2H, is a PEG (polyethylene glycol) linker with an alkyne and carboxylic acid set of functional groups. The alkyne group can participate in copper-catalyzed azide-alkyne Click Chemistry to form stable triazole linkages, while the carboxylic acid can react with primary amines to form stable amide bonds, often requiring an activator such as EDC or HATU.
944561-46-0
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Basic information
- Product Name: Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
- Synonyms: 944561-46-0;Propargyl-PEG2-CH2COOH;2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)acetic acid;Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-;Propargyl-PEG3-CH2CO2H;2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]acetic Acid;2-[2-(2-prop-2-ynoxyethoxy)ethoxy]acetic acid;2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}acetic acid;SCHEMBL2508139;TQR1087;CS-M3521;MFCD30469071;AKOS037650624;BP-28014;CS-15082;HY-41922;SY251179;C13039;EN300-7462425;2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)aceticacid
- CAS NO:944561-46-0
- Molecular Formula: C9H14O5
- Molecular Weight: 202.20
- EINECS: 850-301-3
- Product Categories: N/A
- Mol File: 944561-46-0.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-(CAS DataBase Reference)
- NIST Chemistry Reference: Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-(944561-46-0)
- EPA Substance Registry System: Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-(944561-46-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 944561-46-0(Hazardous Substances Data)
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944561-46-0 Usage
Uses
Used in Bioconjugation:Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, is used as a PEG linker for bioconjugation applications. The alkyne group allows for the formation of stable triazole linkages through copper-catalyzed azide-alkyne Click Chemistry, enabling the attachment of various biomolecules, such as peptides, proteins, or other functional groups, to create stable and functional bioconjugates.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, is used as a component in drug delivery systems. The carboxylic acid group can react with primary amines to form stable amide bonds, allowing for the attachment of drug molecules to PEG linkers, improving their solubility, stability, and bioavailability, as well as potentially reducing their immunogenicity and non-specific interactions with biological systems.
Used in Polymer Science:
In polymer science, Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, is used as a building block for the synthesis of functional polymers. The PEG linker can be incorporated into polymer structures, providing enhanced solubility, stability, and biocompatibility. The alkyne and carboxylic acid functional groups can be further utilized for post-polymerization modifications, enabling the attachment of various functional groups or other polymers to create multifunctional materials with tailored properties.
Check Digit Verification of cas no
The CAS Registry Mumber 944561-46-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,4,5,6 and 1 respectively; the second part has 2 digits, 4 and 6 respectively.Calculate Digit Verification of CAS Registry Number 944561-46:
(8*9)+(7*4)+(6*4)+(5*5)+(4*6)+(3*1)+(2*4)+(1*6)=190
190 % 10 = 0
So 944561-46-0 is a valid CAS Registry Number.
944561-46-0Upstream product
944561-46-0Downstream Products
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Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
