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955977-50-1

PI-3065 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 955977-50-1 Structure

  • Basic information

    1. Product Name: PI-3065
    2. Synonyms: PI-3065;6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine;PI-3065|PI3065;4-(6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine;6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine;6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine PI-3065;PI-3065, >=98%;6-[[4-(Cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
    3. CAS NO:955977-50-1
    4. Molecular Formula: C27H31FN6OS
    5. Molecular Weight: 506.6380432
    6. EINECS: N/A
    7. Product Categories: Inhibitors
    8. Mol File: 955977-50-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.372±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Store in freezer, under -20°C
    8. Solubility: ≥22.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
    9. PKA: 14.80±0.30(Predicted)
    10. CAS DataBase Reference: PI-3065(CAS DataBase Reference)
    11. NIST Chemistry Reference: PI-3065(955977-50-1)
    12. EPA Substance Registry System: PI-3065(955977-50-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 955977-50-1(Hazardous Substances Data)

955977-50-1 Usage

Biological Activity

pi-3065 is a small molecule and selective inhibitor of p110δkinase with an ki value of 1.5nm and ic50 value of 5nm [1].pi-3065 has been reported to selectively inhibit p110δkinase with ki values of 15nm, 110nm, 130nm and 940nm, ic50 values of 5nm, 91nm, 600nm and >10000nm for p110δ, p110α, p110β and p110γ, respectively. in addition, pi-3065 has been revealed to inhibit 4t1 tumour growth and metastasis. pi-3065 has also noted to prolong survival and reduce the incidence of macroscopic metastases and other disease-associated pathologies [1].

Check Digit Verification of cas no

The CAS Registry Mumber 955977-50-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,5,9,7 and 7 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 955977-50:
(8*9)+(7*5)+(6*5)+(5*9)+(4*7)+(3*7)+(2*5)+(1*0)=241
241 % 10 = 1
So 955977-50-1 is a valid CAS Registry Number.

955977-50-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Thieno[3,2-d]pyrimidine, 6-[[4-(cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-

1.2 Other means of identification

Product number -
Other names PI 3065

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:955977-50-1 SDS

955977-50-1Upstream product

955977-50-1Downstream Products

955977-50-1Relevant articles and documents

PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS

-

Page/Page column 112, (2008/06/13)

Thienopyrimidines of formula (Ia) or (Ib): wherein R1, R2, R3, are as defined in the claims.

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