960510-36-5Relevant articles and documents
Regioselective synthesis of dipyrrolopyrazine (DPP) derivatives via metal free and metal catalyzed amination and investigation of their optical and thermal properties
Meti, Puttavva,Lee, Eun-Sil,Yang, Jung-Won,Gong, Young-Dae
, p. 18120 - 18131 (2017)
Pyrazine is an important molecular scaffold employed in organic optoelectronic materials. Here we report efficient methods for the synthesis of dipyrrolopyrazine, and pyrrolothieno-pyrazine derivatives that involve regio-selective amination reactions of dihalo-pyrrolopyrazines. The developed protocol readily affords either 2-amino- or 3-amino-pyrrolopyrazines from the corresponding 2-bromo-3-chloro-5H-pyrrolo[2,3-b]pyrazines. When the amination reactions are carried under metal free under microwave irradiation, 3-amino-pyrrolopyrazines are obtained exclusively. In contrast, Buchwald cross coupling of the 2-bromo-3-chloro-5H-pyrrolo[2,3-b]pyrazines affords only 2-amino-pyrrolopyrazine. The pyrrolopyrazine scaffolds were converted to the respective 1,7- and 1,5-dihydrodipyrrolo[2,3-b]pyrazines derivatives using Sonogashira reactions. A comprehensive study of the optical properties, thermal properties, and molecular packing of the synthesized compounds was carried out. The results indicate that the 1,7-derivatives may be promising organic materials for optoelectronic applications.
METHODS FOR RENAL FUNCTION DETERMINATION
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Paragraph 0152; 0153, (2019/05/15)
The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The method includes administering a pyrazine compound of Formula I to a patient and mo
COMPOSITIONS AND SYSTEMS FOR RENAL FUNCTION DETERMINATION
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Paragraph 0156; 0157, (2019/05/15)
The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at le
COMPOSITIONS AND METHODS FOR ASSESSING EYE VASCULATURE
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Paragraph 0196, (2016/11/28)
The present disclosure relates to compositions and methods for assessing blood vessels and organs of the body, more specifically to methods for assessing the vasculature of the eye.
PYRAZINE DERIVATIVES WITH EXTENDED CONJUGATION AND USES THEREOF
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Page/Page column 25, (2008/06/13)
The present invention relates to pyrazine derivatives capable of absorbing and emanating spectral energy in the visible and/or near infrared spectrum. Pyrazine derivatives of the invention may be administered to a patient in the form of a pharmaceutically
PYRAZINE DERIVATIVES AND USES THEREOF IN RENAL MONITORING
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Page/Page column 24, (2008/06/13)
The present invention relates to pyrazine derivatives such as those represented by Formulas (I) and (II) below. X1 to X4 of the compounds of Formulas I and II may be characterized as electron withdrawing groups. In contrast, Y1