97294-78-5Relevant articles and documents
ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Paragraph 0288; 0291; 0292; 0960; 961; 0962, (2017/06/12)
A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.
SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS
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Page/Page column 73-74, (2008/06/13)
The invention relates to 5-HT6 receptor antagonists. Novel arylamine compounds having the formula: (see formula I) and pharmaceutically acceptable salts and/or esters thereof, wherein - n is 0, 1, 2, 3, or 4; - A, when present is a lower alkyl
Chiral Building Blocks for the Synthesis of Nitrogen-Containing Natural Products, 5. The Enantioselective Synthesis of Optically Active, Benzene Nucleus-Substituted 1-Phenylethylamines from the Corresponding Acetophenones
Bringmann, Gerhard,Geisler, Joerg-Peter,Geuder, Torsten,Kuenkel, Georg,Kinzinger Lioba
, p. 795 - 805 (2007/10/02)
An efficient two-step procedure for the synthesis of enantiomerically pure, benzene nucleus-substituted 1-phenylethylamines 1 is described, with predictable absolute configuration at the stereogenic center: Imine formation from the substituted acetophenones 6 with (S)- or (R)-1-phenylethylamine and subsequent hydrogenation of the resulting Schiff bases 8 over Raney nickel leads to the secondary amines 9 and 10 in high diastereoselectivities.These dibenzylamines are cleaved regioselectively, usually next to the less substituted aromatic ring, giving the desired chiral 1-phenylethylamines 1 in high yields and enantiomeric purities.Scope and limitations of this new and facile approach to the versatile building blocks 1 are reported.
Synthesis and activity of 5-(aminomethylene)-1,3-cyclohexanediones: Enolic analogues of γ-aminobutyric acid
Mann,Humblet,Chambon,Schlichter,Desarmenien,Feltz,Wermuth
, p. 1440 - 1446 (2007/10/02)
Eight 1,3-cyclohexanediones with an aminoalkyl side chain in the 5-position were synthesized as rigid enolic analogues of GABA (γ-aminobutyric acid). Biochemical investigations about their abilities to displace [3H]GABA and [3H]baclo