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CAS

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98138-05-7

2,4-Dichloropteridine is a chemical compound that belongs to the class of organic compounds known as pteridines and derivatives. These are polycyclic compounds containing a pteridine moiety, which is a bicyclic heterocycle made up of a pyrimidine fused to a pyrazine ring. The 2,4-Dichloropteridine is specifically used in the manufacture of pharmaceuticals. While it is useful in these contexts, like many chemicals, care should be taken in its handling due to potential health risks. However, detailed toxicity information for this particular compound is sparse.

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  • 98138-05-7 Structure

  • Basic information

    1. Product Name: 2,4-Dichloropteridine
    2. Synonyms: 2,4-Dichloropteridine;2,4-Dichloropteridine Basic information
    3. CAS NO:98138-05-7
    4. Molecular Formula: C6H2Cl2N4
    5. Molecular Weight: 201.01
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 98138-05-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 290.1±40.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.67 g/cm3
    6. Refractive Index: 1.694
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: -2.66±0.70(Predicted)
    10. CAS DataBase Reference: 2,4-Dichloropteridine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2,4-Dichloropteridine(98138-05-7)
    12. EPA Substance Registry System: 2,4-Dichloropteridine(98138-05-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 98138-05-7(Hazardous Substances Data)

98138-05-7 Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dichloropteridine is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicine and healthcare. Due to its potential health risks, it is essential to handle 2,4-Dichloropteridine with caution during the manufacturing process to ensure the safety of both workers and the final product.

Check Digit Verification of cas no

The CAS Registry Mumber 98138-05-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,1,3 and 8 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 98138-05:
(7*9)+(6*8)+(5*1)+(4*3)+(3*8)+(2*0)+(1*5)=157
157 % 10 = 7
So 98138-05-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H2Cl2N4/c7-4-3-5(10-2-1-9-3)12-6(8)11-4/h1-2H

98138-05-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4-Dichloropteridine

1.2 Other means of identification

Product number -
Other names 2,4-dichloro-pteridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98138-05-7 SDS

98138-05-7Relevant articles and documents

Discovery of 1-methyl-1 H-imidazole derivatives as potent Jak2 inhibitors

Su, Qibin,Ioannidis, Stephanos,Chuaqui, Claudio,Almeida, Lynsie,Alimzhanov, Marat,Bebernitz, Geraldine,Bell, Kirsten,Block, Michael,Howard, Tina,Huang, Shan,Huszar, Dennis,Read, Jon A.,Rivard Costa, Caroline,Shi, Jie,Su, Mei,Ye, Minwei,Zinda, Michael

, p. 144 - 158 (2014/02/14)

Structure based design, synthesis, and biological evaluation of a novel series of 1-methyl-1H-imidazole, as potent Jak2 inhibitors to modulate the Jak/STAT pathway, are described. Using the C-ring fragment from our first clinical candidate AZD1480 (24), optimization of the series led to the discovery of compound 19a, a potent, orally bioavailable Jak2 inhibitor. Compound 19a displayed a high level of cellular activity in hematopoietic cell lines harboring the V617F mutation and in murine BaF3 TEL-Jak2 cells. Compound 19a demonstrated significant tumor growth inhibition in a UKE-1 xenograft model within a well-tolerated dose range.

HETEROCYCLIC JAK KINASE INHIBITORS

-

Page/Page column 75, (2010/04/27)

The present invention relates to compounds of Formula (I) and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds provide a treatment for myeloproliferative disorders and cancer

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