4-Oxobutanoic acid ethyl ester (10138-10-0) 's Synthetic route

Carbon-carbon bond formation by radical addition-fragmentation reactions of O-tert-alkyl enols and O-cyclopropylcarbinyl enols

Cai, Yudong  Roberts, Brian P.

Terminal alkenes of the type H₂C=C(OR¹)X, in which R¹ is a tertiary alkyl or a 1-cyclopropylethyl group and X=Ph, OSiMe₂Bu^t, OEt or H, undergo radical-chain reactions with organic halides R²Hal to give carbonyl compounds R²CH₂C(=O)X.