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Relevant articles and documents
An improved and single-pot process for the production of pantoprazole substantially free from sulfone impurity
Mathad, Vijayavitthal T. Govindan, Shanmugam Kolla, Naveen Kumar Maddipatla, Madhavi Sajja, Eswaraiah Sundaram, Venkataraman
Pantoprazole (1), a substituted benzimidazole derivative, is an irreversible proton pump inhibitor, essentially used for the prevention and treatment of gastric acid-related diseases. The process for its preparation generally suffers from the drawback of producing a potential sulfone impurity (5). The present work details a report of the journey towards the development of a simple, single-pot process for the production of pantoprazole, substantially free from sulfone impurity (5). The detailed study of the different parameters affecting the purity and yield of the compound has been presented.
Application of continuous flow micromixing reactor technology for synthesis of benzimidazole drugs
Reddy, Gunupati Sharathchandra Reddy, Narra Santosh Manudhane, Kushal Rama Krishna, Medisetti Venkata Ramachandra, Kopparapu Janardana Sarma Gangula, Srinivas
Synthesis of pharmaceutically active compounds by employing continuous flow micromixing reactor technology is an interesting research area. In this article we describe the synthesis of benzimidazole core drugs, such as lansoprazole (1a), pantaprazole (1b), and rabeprazole (1c) by using a continuous flow micromixing reactor technology. A key feature of the sulfoxidation includes the decreasing the reaction time from 3 h to ～1 s to minimize the formation of sulfone impurities and improve the yields.
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