Phenylacetic acid (103-82-2) 's Synthetic route

Synthesis, crystal structure of Co(II)(6-methoxybenzothiazole-2-carboxylate)₂(DMF)₂ and its application to carbonylation of benzyl chloride

Zhang, Bin  Li, Jianli  Chen, Wei  Wang, Yunxia  Shi, Zhen

A new complex, Co(MBTC)₂(DMF)₂ (MBTC(6-methoxybenzothiazole-2-carboxylate, DMF=N,N-dimethylformamide), was synthesized in DMF solution and characterized by single crystal X-ray diffraction analysis. Using the cobalt complex as catalyst, phenylacetic acid was prepared by the carbonylation of benzyl chloride with carbon monoxide (0.1 MPa). The effects of solvents, phase transfer catalysts and temperature on the reactions were investigated. The yield of phenylacetic acid was higher than 90% in optimized condition.

• 
• 
• 

Lanthanide-Promoted and Nickel Cyanide Catalyzed Carbonylation Reactions under Phase-Transfer Conditions

Amer, Ibrahim  Alper, Howard

The nickel cyanide and phase transfer catalyzed carbonylation of benzyl chlorides is promoted by lanthanide salts .This simple reaction is sensitive to the concentration of the lanthanide compound, sodium hydroxide, quaternary ammonium salt, and nickel catalyst.The nature of the organic phase and phase transfer agent also influences the reaction rate.The acceleration of the reaction may be a consequence of coordination of a nickel cyanide nitrogen lone pair to the lanthanide salt.

• 
• 
•