(RS)-N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride (116817-11-9) 's Synthetic route

N-Fluorolactams: Rapid, Mild, and Regiospecific Fluorinating Agents

Satyamurthy, N.  Bida, Gerald T.  Phelps, Michael E.  Barrio, Jorge R.

Solvent effects in the fluorination of aromatic molecules with 'F-TEDA-BF4'

Zupan, Marko  Iskra, Jernej  Stavber, Stojan

The type of functionalization of an aromatic molecule achieved with 1-chloro-4-fluoro-1,4-diazobicyclo-(2,2,2)octane bis-tetrafluoroborate, 'F-TEDA-BF4', in trifluoroacetic acid depends on its structure: naphthalene and phenanthrene gave fluorinated products, anthracene gave the trifluoroacetate, while an addition process occurred with 9-methoxy-phenanthrene in methanol, and an addition-elimination process in trifluoroacetic acid. - Keywords: Solvent effects; Fluorination; Aromate molecules; F-TEDA-BF4; Structural effects; Addition processes