Relevant articles and documents
Synthesis, characterization of 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline and its crystal structure
Xu, Jia-Ying Cheng, Wei-Hua Wang, Lan Wu, Jian-Guo Wang, Kai
3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline (I), an important intermediate to synthesize pitavastatin calcium. It was prepared from ethyl 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxylate via reduction by KBH4/ZnCl2 and then bromide by PBr3. The product was characterized by NMR and LC-MS. The crystal structure of compound I was investigated using X-ray diffraction and SHELXTL-97 software. The result indicated that compound I crystallized in the triclinic system, space group P-1 with a = 9.6150(19), b = 9.868 (2), c = 10.060(2) ?, V = 783.3 (4) ?3; Z 2.
Practical synthesis of quinoline nucleus of NK-104
Suzuki, Mikio Tanikawa, Keizo Sakoda, Ryozo
The development of practical synthetic procedure for a staple intermediate of NK-104, a highly advanced HMG-Co.A reductase inhibitor is reported.
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