4'-Fluoro-2'-hydroxyacetophenone (1481-27-2) 's Synthetic route

A practical synthesis of 2'-fluoro-4'-hydroxyacetophenone

Zhang, Xiao-Bo  Lu, Qun  Xu, Wei-Ming

Process development and manufacture of potassium 2-fluoro-6-hydroxyphenyltrifluoroborate

Pawar, Lokesh  Jayaramaiah, Ramesh  Krishnan, Baburaj  Arunachalampillai, Athimoolam  Chen, Ying  Parsons, Andrew T.  Robinson, Jo Anna  Tedrow, Jason S.

The development of a phase-appropriate manufacturing-scale synthesis of potassium 2-fluoro-6-hydroxyphenyltrifluoroborate was achieved. Investigations into improving the yield and robustness indicated that pH of the reaction medium is a critical process parameter. Additional development resulted in replacing tartaric acid with citric acid, resulting in improved process robustness and enabling scale-up to >10 kg.