3-hydroxy-3-phenyl-butan-2-one (3155-01-9) 's Synthetic route

Collision-induced fragmentation of ionized 3-phenyl-1-butyn-3-ol mediated by an intermediate proton-bound complex [3]

She  Tu  Song  Liu

Synthesis of alkyne derivatives of a novel triazolopyrazine as A _2A adenosine receptor antagonists

Yao, Gang  Haque, Serajul  Sha, Li  Kumaravel, Gnanasambandam  Wang, Joy  Engber, Thomas M.  Whalley, Eric T.  Conlon, Patrick R.  Chang, Hexi  Kiesman, William F.  Petter, Russell C.

A novel [1,2,4]triazolo[1,5-a]pyrazine core was synthesized and coupled with terminal acetylenes. The structure-activity relationship of the alkynes from this novel template was studied for their in vitro and in vivo adenosine A_2A receptor antagonism. Selected compounds from this series were shown to have potent in vitro and in vivo activities against adenosine A _2A receptor. Compound 12, in particular, was found to be orally active at 3 mg/kg in both a mouse catalepsy model and a 6-hydroxydopamine- lesioned rat model.