5,5-dihydroxyperhydropyrimidinetrione (3237-50-1) 's Synthetic route

The crystal structure of 5,5-dihydroxybarbituric acid trihydrate.

Mootz  Jeffrey

Insights into the biological redox chemistry of 2′-deoxyadenosine 5′-monophosphate by electrochemical techniques

Goyal, Rajendra N.  Dhawan, Aikta

The electrochemical oxidation of 2′-deoxyadenosine 5′-monophosphate at a pyrolytic graphite electrode (PGE) was studied in the pH range 2.65-10.03 and was found to proceed in a single well-defined oxidation peak, I_a, over the entire pH range. The cyclic voltammetric behavior indicated the pH dependence of the oxidation pathway. The kinetic studies of the UV-absorbing intermediate generated during electrooxidation were followed spectrophotometrically, and decay occurred in a pseudo first-order reaction having k values in the range (0.595-0.986) × 10^-3 s^-1 over the entire pH range studied. Coulometric studies indicated that the process of the oxidative pathway involved n values as 5.0 ± 0.5 in the acidic range (pH 3.37) and 4.0 ± 0.5 at physiological pH 7.22. The products of electrooxidation were characterized by GC-MS and on the basis of electrochemical, spectrochemical, and product analysis; a plausible redox mechanism is suggested.