Tranilast (53902-12-8) 's Synthetic route

Double asymmetric intramolecular aza-Michael reaction: a convenient strategy for the synthesis of quinolizidine alkaloids

Alzuet-Pi?a, Gloria  Escolano, Marcos  Sánchez-Roselló, María  Torres, Javier  del Pozo, Carlos

A new methodology to access the quinolizidine skeleton in an asymmetric fashion was devised. It involves two consecutive intramolecular aza-Michael reactions of sulfinyl amines bearing a bis-enone moiety, in turn generated by a monodirectional cross metat