3-Nitrophthalic anhydride (641-70-3) 's Synthetic route

Solvent-free synthesis of new chalcone derivatives from 3-nitro phthalic acid and evaluation of their biological activities

Ahamed, Luma S.  Ali, Rana Abid  Ahmed, Rana S.

Synthesis of 2-(4-Acetyl-phenyl)-4-nitro-isoindole-1, 3-dione chalcones were performed by fusion of 3-nitro phthalic anhydride with p-aminoacetophenone. Then the later was grinded with different aromatic aldehydes in the presence of sodium hydroxide to produce new chalcones derivatives A3-10 without using any solvent formation of new Narylphthailimide chalcones were confirmed by FT-IR,1HNMR, 13CNMR spectroscopy and all final compounds were tested for their antifungal and antibacterial activity some of them showed more biological activity than the standard drugs.