1,10-Diaminodecane (646-25-3) 's Synthetic route

New synthetic technology for the mild and selective one-carbon homologation of hindered aldehydes in the presence of ketones

Nicolaou  Vassilikogiannakis, Georgios  Kranich, Remo  Baran, Phil S.  Zhong, Yong-Li  Natarajan, Swaminathan

(Formula presented) A selective, mild, and highly efficient method has been uncovered during the total synthesis of the CP molecules to accomplish the one-carbon homologation of sterically hindered aldehydes in the presence of acid- and base-labile moieties, Michael acceptors, and even other carbonyl groups such as reactive and epimerizable ketones. Mechanistic studies have revealed a neutral reagent for the rapid collapse of cyanohydrins to ketones.