![1H-Pyrrole-2-carboxylic acid, 4-[[(1,1-diMethylethoxy)carbonyl]aMino]-1-Methyl-, Methyl ester](http://file1.lookchem.com/cas/reactions/2021/08/14/6411947.png)
Relevant articles and documents
Guanine-Containing DNA Minor-Groove binders
Pulido, Daniel Sanchez, Albert Robles, Jordi Pedroso, Enrique Grandas, Anna
Solid-phase procedures have been used to prepare six di-pyrrole-containing DNA ligands that combine (guanin-9-yl)-acetyl, (guanin-7-yl)acetyl or acetyl moieties at the N-terminal end and two lysines or a (dimethylamino)propyl group at the C terminus. Inspection of their DNA-stabilizing properties by UV-monitored thermal denaturation experiments showed that the ligand incorporating the (guanin-9-yl)acetyl group and the (dimethylamino)propyl tail had the highest duplex-stabilizing effects. Wiley-VCH Verlag GmbH & Co, KGaA.
Synthesis of pyrrole-imidazole polyamide oligomers based on a copper-catalyzed cross-coupling strategy
Shiga, Naoki Takayanagi, Shihori Muramoto, Risa Murakami, Tasuku Qin, Rui Suzuki, Yuta Shinohara, Ken-ichi Kaneda, Atsushi Nemoto, Tetsuhiro
Pyrrole-imidazole (Py-Im) polyamides are useful tools for chemical biology and medicinal chemistry studies due to their unique binding properties to the minor groove of DNA. We developed a novel method of synthesizing Py-Im polyamide oligomers based on a Cu-catalyzed cross-coupling strategy. All four patterns of dimer fragments could be synthesized using a Cu-catalyzed Ullmann-type cross-coupling with easily prepared monomer units. Moreover, we demonstrated that pyrrole dimer, trimer, and tetramer building blocks for Py-Im polyamide synthesis were accessible by combining site selective iodination of the pyrrole/pyrrole coupling adduct.
Italy | Contact:Chemper
United Kingdom | Contact:Elsa Young
China (Mainland) | Contact:Guan