Bicalutamide (90357-06-5) 's Synthetic route

Nucleophilic Aromatic Substitution of Methacrylamide Anion and Its Application to the Synthesis of the Anticancer Drug Bicalutamide

Chen, Bang-Chi  Zhao, Rulin  Gove, Stacey  Wang, Bei  Sundeen, Joseph E.  Salvati, Mark E.  Barrish, Joel C.

The anticancer drug (R,S)-biscaltamide was prepared in three steps in >90% overall yield. A key step in the new synthesis involved a new nucleophilic aromatic substitution reaction of methacrylamide anion.