Products Categories
CAS No.: | 132-20-7 |
---|---|
Name: | Pheniramine maleate |
Article Data: | 1 |
Molecular Structure: | |
Formula: | C16H20N2.C4H4O4 |
Molecular Weight: | 356.422 |
Synonyms: | dimethyl-[3-phenyl-3-(1H-pyridin-6-yl)propyl]azanium; propanedioate;Prestwick_769;Naphcon A;2-Pyridinepropanamine,N,N-dimethyl-?- phenyl-,(2Z)-2-butenedioate (1:1);but-2-enedioic acid; N,N-dimethyl-3-phenyl-3-pyridin-2-yl-propan-1-amine;Pheniramine maleate (JAN/USP); |
EINECS: | 205-051-4 |
Density: | 1.2233 (rough estimate) |
Melting Point: | 104-108 °C |
Boiling Point: | 348.3 °C at 760 mmHg |
Flash Point: | 164.5 °C |
Solubility: | >=1 g/100 mL at 24 °C in water |
Appearance: | white powder |
Hazard Symbols: | Xn |
Risk Codes: | 22 |
Safety: | 36 |
PSA: | 90.73000 |
LogP: | 2.87700 |
Conditions | Yield |
---|---|
In ethanol at 20℃; Solvent; | 5.1 g |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; tetrahydrofuran; water / 3 h / 75 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C 3: ethanol / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; tetrahydrofuran; water / 3 h / 75 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C 3: ethanol / 20 °C View Scheme |
pheniramine maleate
Conditions | Yield |
---|---|
With CH3COOH In acetic acid byproducts: CH3COOK, H2O, HCN; aq. acetic acid; 20-30 min, 80°C; CO2 bubbled (few h) to remove HCN; ppt. washed (H2O repeatedly; ethanol); dried (vac., over silica gel, room temp., to const. wt.); elem.anal.; | 59% |
pheniramine maleate
Conditions | Yield |
---|---|
In water; acetic acid addn. of ligand in a mixt. of water/acetic acid to a filtered aq. soln. of molybdate with shaking, refluxing for 4-5 h over a hot plate at 80°C; filtn. by suction, washing several times with dilute acetic acid, finally with water, drying in vacuo at room temp. to a constant weight, elem. anal.; | 53% |
pheniramine maleate
Conditions | Yield |
---|---|
In acetic acid aq. acetic acid; shaking, reflux (80°C, 1-2 h), ice cooling, pptn.; filtration, washing (CH3COOH(aq.), water), drying (vac., room temp.); elem. anal.; | 45% |
Conditions | Yield |
---|---|
In water; acetic acid adding aq.-AcOH soln. of ligand to aq. soln. of Cr complex with shaking,refluxing for 30-45 min at 80°C; filtering ppt. by suction, washing with dild. AcOH and water, drying in vacuo; elem. anal.; | 42% |
IUPAC Name: 1-(N,N-Dimethylamino)-3-(phenyl-3-a-pyridyl)propane maleate
The MF of 1-(N,N-Dimethylamino)-3-(phenyl-3-a-pyridyl)propane maleate (132-20-7) is C20H24N2O4.
The MW of 1-(N,N-Dimethylamino)-3-(phenyl-3-a-pyridyl)propane maleate (132-20-7) is 356.42.
Synonyms of 1-(N,N-Dimethylamino)-3-(phenyl-3-a-pyridyl)propane maleate (132-20-7): Prophenpyridamine maleate ; Pheniramine maleate ; Pheniramine maleate salt ; P1-(N,N-Dimethylamino)-3-(phenyl-3-alpha-pyridyl)propanemaleate ; 2-(Alpha-(2-(dimethylamino)ethyl)benzyl)pyridine,bimaleate ; 2-(Alpha-(2-(dimethylamino)ethyl)benzyl)pyridine,maleate ; 2-(Alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1)
Product Categories: Antagonists;Histaminergics;Neurotransmitters
Stability: Stable. Incompatible with strong oxidizing agents
Apperance: White powder with a faint amine-like odor
Water Solubility: >=1 g/100 mL at 24 ºC
Flash Point: 164.5 °C
Boiling Point: 348.3 °C
Melting Point: 104-108 °C
EINECS: 205-051-4
1-(N,N-Dimethylamino)-3-(phenyl-3-a-pyridyl)propane maleate (132-20-7) is used medicinally as an antihistaminic.
Pheniramine maleate gives weakly acidic aqueous solutions. May react with strong oxidizing agents.
1. | cyt-mus-orl 1120 µg/kg | IJEBA6 Indian Journal of Experimental Biology. 19 (1981),516. | ||
2. | orl-hmn LDLo:30 mg/kg | ATXKA8 Archiv fuer Toxikologie. 29 (1972),317. | ||
3. | orl-rat LD50:520 mg/kg | KIZAAL Kurume Igakkai Zasshi. Journal of the Kurume Medical Association. 43 (1980),168. | ||
4. | scu-rat LDLo:200 mg/kg | CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. 144 (1950),887. | ||
5. | orl-mus LD50:268 mg/kg | KIZAAL Kurume Igakkai Zasshi. Journal of the Kurume Medical Association. 43 (1980),168. | ||
6. | ivn-dog LDLo:111 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 113 (1955),72. | ||
7. | ivn-gpg LD50:72 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 113 (1958),313. |
Reported in EPA TSCA Inventory.
Human poison by ingestion. Experimental poison by ingestion, subcutaneous, and intravenous routes. Mutation data reported. Used as an antihistamine. When heated to decomposition it emits toxic fumes of NOx.
Safety information of 1-(N,N-Dimethylamino)-3-(phenyl-3-a-pyridyl)propane maleate (132-20-7):
Hazard Codes Xn
Risk Statements
22 Harmful if swallowed
Safety Statements
36 Wear suitable protective clothing
WGK Germany 3
RTECS UT0175000