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CAS No.: | 672-15-1 |
---|---|
Name: | L-Homoserine |
Article Data: | 45 |
Molecular Structure: | |
Formula: | C4H9NO3 |
Molecular Weight: | 119.12 |
Synonyms: | Butyric acid, 2-amino-4-hydroxy-, L- (8CI);Butanoic acid, 2-amino-4-hydroxy-, (S)-;2-amino-4-hydroxy-butanoic acid;2-Amino-4-hydroxybutyric acid;Butyric acid, 2-amino-4-hydroxy-, L-;(2S)-2-amino-4-hydroxy-butanoic acid;Homoserine (VAN);H-Homoserine;H-Hse-OH;L-Homo-serine;H-HoSer-OH; |
EINECS: | 211-590-6 |
Density: | 1.3126 (rough estimate) |
Melting Point: | 203 °C |
Boiling Point: | 368.7 °C at 760 mmHg |
Flash Point: | 176.8 °C |
Solubility: | 1100 g/L (30 °C) in water |
Appearance: | white to light yellow crystalline powder |
Risk Codes: | 36/37/38 |
Safety: | 24/25 |
PSA: | 83.55000 |
LogP: | -0.51900 |
Isopropyl (2S)-N-(trifluoroacetyl)homoserine
L-homoserine
Conditions | Yield |
---|---|
With ethanol | 95% |
With potassium hydroxide In ethanol for 2h; | 95% |
Conditions | Yield |
---|---|
With water; sodium hydrogencarbonate pH=2 - 5; Reflux; | 92% |
With sodium hydrogencarbonate In water pH=3 - 6; Inert atmosphere; Schlenk technique; Reflux; | 92% |
With sodium hydrogencarbonate In water at 140℃; for 0.5h; | 69% |
Conditions | Yield |
---|---|
With triethylamine In water for 2h; Ambient temperature; | 82% |
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-N-(4-L-aspartoyl)-2-deoxy-β-D-glucopyranosylamine
A
L-homoserine
B
N,N'-diacetylchitobiosamine
C
1-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-amino-1,2-dideoxy-D-glucitol
D
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-amino-1,2-dideoxy-D-glucitol
Conditions | Yield |
---|---|
With lithium hydroxide; lithium borohydride; trilithium citrate In water; tert-butyl alcohol at 45℃; for 5h; Yield given; | A 80% B 72% C n/a D n/a |
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-N-(4-L-aspartoyl)-2-deoxy-β-D-glucopyranosylamine
A
L-homoserine
B
N,N'-diacetylchitobiosamine
C
1-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-amino-1,2-dideoxy-D-glucitol
D
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-amino-1,2-dideoxy-D-glucitol
E
β-D-GlcpNAc(1->4)-D-GlcNAc-ol
Conditions | Yield |
---|---|
With lithium hydroxide; lithium borohydride; trilithium citrate In water; tert-butyl alcohol at 45℃; for 5h; Product distribution; | A 80% B 72% C n/a D n/a E 5% |
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-N-(4-L-aspartoyl)-2-deoxy-β-D-glucopyranosylamine
A
L-homoserine
B
N,N'-diacetylchitobiosamine
C
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-amino-1,2-dideoxy-D-glucitol
D
β-D-GlcpNAc(1->4)-D-GlcNAc-ol
Conditions | Yield |
---|---|
With lithium hydroxide; lithium borohydride; trilithium citrate In water; tert-butyl alcohol at 45℃; for 5h; | A 80% B 72% C n/a D 5% |
Conditions | Yield |
---|---|
With water; methyl iodide at 20℃; for 24h; Inert atmosphere; Reflux; | 74% |
Stage #1: L-methionine With methyl iodide In water for 24h; Inert atmosphere; Stage #2: With potassium hydrogencarbonate for 10h; pH=3 - 6; Reflux; Stage #3: With hydrogenchloride In water pH=5 - 6; | 74% |
Stage #1: L-methionine With methyl iodide In methanol; water for 48h; Stage #2: With sodium hydrogencarbonate In methanol; water for 15h; Reflux; | 62% |
With sodium hydrogencarbonate; methyl iodide In methanol; water for 12h; Reflux; |
(S)-tert-butyl 1-(furan-2-yl)-3-hydroxypropylcarbamate
L-homoserine
Conditions | Yield |
---|---|
Stage #1: (S)-tert-butyl 1-(furan-2-yl)-3-hydroxypropylcarbamate With ozone In methanol at -78℃; for 0.166667h; Stage #2: With dimethylsulfide In methanol at 20℃; for 12h; Stage #3: With hydrogenchloride In 1,4-dioxane at 0 - 20℃; | 62% |
L-methionine
ptaquiloside
A
L-homoserine
B
2(R)-pterosin B
C
(R)-2,5,7-Trimethyl-6-(2-methylsulfanyl-ethyl)-indan-1-one
D
(S)-2-Amino-4-methylsulfanyl-butyric acid 2-((R)-2,4,6-trimethyl-3-oxo-indan-5-yl)-ethyl ester
Conditions | Yield |
---|---|
With sodium hydroxide; Amberlite CG 50 (H form) In water; acetone at 37℃; for 12h; 1.) pH: 9.2; | A 10% B 26% C 12% D 4% |
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-N-(4-L-aspartoyl)-2-deoxy-β-D-glucopyranosylamine
A
L-homoserine
B
L-Aspartic acid
C
β-D-GlcpNAc(1->4)-D-GlcNAc-ol
Conditions | Yield |
---|---|
With sodium hydroxide; sodium tetrahydroborate | A 15% B 3% C 20% |
IUPAC Name: 2-Amino-4-hydroxybutanoic acid
Synonyms of L-Homoserine (CAS NO.672-15-1): Butanoic acid, 2-amino-4-hydroxy-, (S)- ; Homoserine (VAN) ; Butyric acid, 2-amino-4-hydroxy-, L- (8CI)
CAS NO: 672-15-1
Molecular Formula: C4H9NO3
Molecular Weight: 119.12
Molecular Structure:
EINECS: 211-590-6
H bond acceptors: 4
H bond donors: 4
Freely Rotating Bonds: 5
Polar Surface Area: 38.77 Å2
Index of Refraction: 1.51
Molar Refractivity: 27.17 cm3
Molar Volume: 90.7 cm3
Surface Tension: 63.5 dyne/cm
Density: 1.312 g/cm3
Flash Point: 176.8 °C
Enthalpy of Vaporization: 71.22 kJ/mol
Boiling Point: 368.7 °C at 760 mmHg
Vapour Pressure: 6.16E-07 mmHg at 25°C
Melting Point: 203 °C (dec.)(lit.)
Alpha: -8.5 º (c=2, H2O 22 ºC)
Storage temp: Store at RT.
Water Solubility: 1100 g/L (30 °C)
Appearance: white to light yellow crystalline powder
Product Categories of L-Homoserine (CAS NO.672-15-1): Serine [Ser, S];Unusual Amino Acids;Amino Acids;Amino Acids & Derivatives
L-Homoserine (CAS NO.672-15-1) is an intermediate in the biosynthesis of three essential amino acids: methionine, threonine (an isomer of homoserine), and isoleucine.
Safety Information about L-Homoserine (CAS NO.672-15-1):
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes.
WGK Germany: 3
F: 10
HS Code: 29225000
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container. Keep refrigerated. (Store below 4°C/39°F.)