4799-69-3

Basic information

• Product Name: 4-(Benzyloxy)-2-butanol
• Synonyms: 4-(Benzyloxy)-2-butanol
• CAS NO: 4799-69-3
• Molecular Formula: C₁₁H₁₆O₂
• Molecular Weight: 180.24
• Mol File: 4799-69-3.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 151-152 °C
• Appearance: /
• Density: 1.0220 g/cm3
• PKA: 14.95±0.20(Predicted)
• CAS DataBase Reference: 4-(Benzyloxy)-2-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Benzyloxy)-2-butanol(4799-69-3)
• EPA Substance Registry System: 4-(Benzyloxy)-2-butanol(4799-69-3)

Safety Data

• Hazardous Substances Data: 4799-69-3(Hazardous Substances Data)

Upstream product

• 774-44-7 4-methyl-2-phenyl-[1,3]dioxane 
• 393109-23-4 (S)-((4-(benzyloxy)butan-2-yl)oxy)(tert-butyl)dimethylsilane 
• 128385-64-8 acetic acid-(3-benzyloxy-1-methyl-propyl ester) 
• 1414787-03-3 C₁₆H₂₂O₅ 
• 1414787-02-2 C₁₅H₂₀O₅ 
• 115114-87-9 (2R)-2-(2-benzyloxyethyl)oxirane 
• 70388-33-9 4-benzyloxybut-1-ene 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 393109-25-6 2,2-Dimethyl-propionic acid (S)-4-benzyloxy-2-methanesulfonyloxy-butyl ester 
• 393109-24-5 2,2-Dimethyl-propionic acid (S)-4-benzyloxy-2-hydroxy-butyl ester 
• 71998-69-1 (S)-4-benzyloxy-1,2-butanediol 
• 6278-91-7 4-(benzyloxy)-2-butanone 

Downstream Products

• 167778-41-8 (3-Benzyloxy-1-methyl-propoxy)-acetic acid 
• 4799-69-3 (S)-(-)-1,3-butanediol 1-benzyl ether 
• 77564-44-4 (R)-(+)-1,3-butanediol 1-benzyl ether 
• 1414787-02-2 C₁₅H₂₀O₅ 
• 1414787-03-3 C₁₆H₂₂O₅ 
• 91244-85-8 ((3-chlorobutoxy)methyl)benzene 
• 107290-85-7 ((S)-3-Methyl-undecyloxymethyl)-benzene 
• 106539-41-7 3(S)-1-benzyloxy-3-phtalimidobutane 
• 77564-41-1 (R)-1,3-butanediol 1-benzyl ether 3-THP ether 
• 106539-39-3 [(1R)-3-benzyloxy-1-methylpropyl] acetate 
• 393109-23-4 (S)-((4-(benzyloxy)butan-2-yl)oxy)(tert-butyl)dimethylsilane 
• 77564-45-5 (R)-1,3-butanediol 1-benzyl ether 3-benzoate 
• 84184-35-0 Toluene-4-sulfonic acid 3-benzyloxy-1-methyl-propyl ester 
• 84184-35-0 Benzyl 3-tosyloxybutyl ether 

Relevant articles and documents

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Stereoselective synthesis of resorcylic acid lactone Cochliomycin B

The total synthesis of 14-membered resorcylic acid lactone, Cochliomycin B has prescribed, in a convergent manner, from readily available starting materials, D-galactose, L-aspartic acid and ethyl acetoacetate. The key reactions involved in the synthesis are Julia-Kocienski olefination, E-selective Horner-Wadsworth-Emmons olefination and intramolecular lactonization.

Regio/site-selective alkylation of substrates containing a: Cis -, 1,2- or 1,3-diol with ferric chloride and dipivaloylmethane as the catalytic system

In this study, we reported the regio/site-selective alkylation of substrates containing a cis-, 1,2- or 1,3-diol with FeCl3 as a key catalyst. A catalytic system consisting of FeCl3 (0.01-0.1 equiv.) and dipivaloylmethane (FeCl3/dipivaloylmethane = 1/2) was used to catalyze the alkylation in the presence of a base. The produced selectivities and isolated yields were similar to those obtained by methods using the same amount of FeL3 (L = acylacetone ligand) as the catalyst in most cases. The previously reported FeL3 catalysts for alkylation are not commercially available and have to be synthesized prior to use. In contrast, FeCl3 and dipivaloylmethane (Hdipm) are very common and inexpensive nontoxic reagents in the lab, thereby making the method much greener and easier to handle. Mechanism studies confirmed for the first time that FeCl3 initially reacts with two equivalents of Hdipm to form [Fe(dipm)3] in the presence of a base in acetonitrile, followed by the formation of a five or six-membered ring intermediate between [Fe(dipm)3] and two hydroxyl groups of the substrate. A subsequent reaction between the cyclic intermediate and the alkylating agent results in selective alkylation of the substrate.