106560-14-9 Usage
Description
Faropenem sodium hemipentahydrate is a broad-spectrum oral penem antibiotic that is β-lactamase stable. It was launched in Japan for use as an antibiotic against common respiratory tract pathogens and can be prepared through several related routes of about seven steps starting with tetrahydrofuran-2-thiocarboxylic acid and a silylated azetidinone.
Uses
Used in Pharmaceutical Industry:
Faropenem sodium hemipentahydrate is used as an antibiotic for the treatment of bacterial infections. It is effective against a wide range of bacteria, including anaerobes, Gram-positive, Gram-negative, and enterobacteriaceae. Faropenem is more active against anaerobes than cefaclor, cefixime, and amoxicillin and is equally active against strains carrying plasmid and chromosome-mediated β-lactamases.
Faropenem sodium hemipentahydrate is also used as a compound in organic synthesis, contributing to the development of new pharmaceutical products.
Brand name: Farom
Originator
Suntory (Japan)
Antimicrobial activity
An orally active penem with a broad spectrum of antibacterial
activity, including activity against selected anaerobic
pathogens. Although it is active against most enterobacteria, it has reduced activity against Ser. marcescens,
Enterobacter spp. and some Providencia spp. It generally
retains activity against many Gram-positive organisms,
but has no useful activity against Ps. aeruginosa. It has
reduced activity against E. faecium, methicillin-resistant
Staph. aureus (MRSA) and some strains of coagulase-negative
staphylococci. It is stable to hydrolysis by extended
spectrum β-lactamases, but is hydrolyzed by carbapenemases.
Esterified prodrugs with increased bioavailability
have been studied in clinical trials but have not received
regulatory approval.
Check Digit Verification of cas no
The CAS Registry Mumber 106560-14-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,5,6 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 106560-14:
(8*1)+(7*0)+(6*6)+(5*5)+(4*6)+(3*0)+(2*1)+(1*4)=99
99 % 10 = 9
So 106560-14-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H15NO5S/c1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6/h5-7,11,14H,2-4H2,1H3,(H,16,17)/t5-,6-,7+,11-/m1/s1
106560-14-9Relevant articles and documents
A synthesis method of faropenem sodium
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Paragraph 0015; 0036; 0037, (2017/07/14)
The invention provides a method for synthesizing faropenem sodium. According to the method, oxalic acid chloride p-nitrobenzyl ester is used for replacing allyloxy oxalyl chloride in a conventional process, and thus the generation of polymer impurities is effectively prevented, and the raw material conversion rate and the product yield are increased; by adopting a method of catalytic hydrogenation under an acidic condition, silylation protection groups and p-nitrobenzyl ester protection groups are removed, organophosphorus impurities which are difficult to treat are effectively prevented, the separation and purification of products are facilitated, the maneuverability is improved, and the industrialized production is facilitated.
SOUP FAROPENEM FREE ACID
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Page/Page column 7-8, (2008/06/13)
The present invention provides solid form of faropenem free acid, its hydrates and processes for their preparation thereof. Thus, for example, dissolving an alkali metal salt of faropenem in water, adjusting the pH of the solution formed with an acid to below about 2.5 and collecting the precipitated solid to obtain solid faropenem free acid.