117428-22-5Relevant articles and documents
Preparation method of picoxystrobin
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Paragraph 0037; 0055-0070, (2021/04/21)
The invention belongs to the technical field of bactericides, and particularly relates to a preparation method of picoxystrobin. The invention provides a preparation method of picoxystrobin, which comprises the following steps: mixing 2-(6-trifluoromethylpyridine-2-yloxymethyl) methyl phenylacetate, acetic anhydride and trimethyl orthoformate, and carrying out condensation reaction to obtain the picoxystrobin. According to the invention, 2-(6-trifluoromethylpyridine-2-yloxymethyl) methyl phenylacetate, acetic anhydride and trimethyl orthoformate are used as raw materials, and the 2-(6-trifluoromethylpyridine-2-yloxymethyl) methyl phenylacetate and trimethyl orthoformate are subjected to a condensation reaction under the action of acetic anhydride to obtain picoxystrobin; and acetic anhydride can react with a condensation reaction byproduct to reduce the content of the condensation reaction byproduct, promote the condensation reaction and improve the yield of picoxystrobin. The preparation method provided by the invention is simple in process, mild in reaction condition, low in production cost and beneficial to industrial production.
Method for synthesis -2- of 3- methyl ester compound (methyl ethyl ester) of methyl ethyl ester (methyl) ethyl ester
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Paragraph 0030-0045, (2019/12/25)
The invention relates to a synthesis method of 3-methoxy-2-aryl(methyl)acrylate compounds, which comprises the following steps: by using phenylmethyl acetate with or without substituting groups as a raw material, carrying out formylation reaction at -20-100 DEG C for 4-6 hours in a nitrogen atmosphere in the presence of Lewis acid in an aprotic solvent neutralized formylation reagent, dissociating with an organic base, hydrolyzing with hydrochloric acid, and stratifying, wherein the organic layer is an intermediate; carrying out methylation reaction on the intermediate, benzyltriethylammonium chloride, a methylation reagent and an inorganic base at 20-100 DEG C for 1-3 hours; after the reaction finishes, washing with water, desolventizing, and recrystallizing or distilling while depressurizing to obtain the product. The invention has the advantages of fewer processing steps (the methylation reaction can be directly carried out without purifying and separating the intermediate product), favorable selectivity, higher yield and low cost; and the reaction process is easy to control, and is safe and easy to amplify.
Silver-Catalyzed Olefination of Acetals and Ketals with Diazoesters to β-Alkoxyacrylates
Li, Jiawen,Qian, Bo,Huang, Hanmin
supporting information, p. 7090 - 7094 (2018/11/23)
The first silver-catalyzed reaction of acetals or ketals with diazoesters leading to trisubstituted or tetrasubstituted β-alkoxyacrylates is now reported. A broad range of acetals and ketals bearing different substituents is compatible with this protocol and thus provides an attractive approach for the synthesis of complex β-alkoxyacrylates. The power of this method was further demonstrated by the successful synthesis of picoxystrobin, which is one of the most popular agricultural fungicides commercialized by Dupont.