34486-06-1Relevant articles and documents
Preparation method of 2-hydroxy-6-trifluoromethylpyridine
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, (2021/07/31)
The invention provides a preparation method of 2-hydroxy-6-trifluoromethylpyridine. The method comprises the following steps of: carrying out Grignard reaction on trifluorohalomethane and magnesium powder to prepare a Grignard reagent; reacting the obtained Grignard reagent with 1, 5-glutaric acid diester, and then acidifying to obtain 4-trifluoroacetyl butyrate; then, carrying out cyclization reaction on the 4-trifluoroacetyl butyrate and ammonia to obtain 6-trifluoromethyl-3, 4-dihydropyridine-2-ketone; and then carrying out an oxidation reaction to obtain the 2-hydroxy-6-trifluoromethylpyridine. The raw materials used in the method are cheap, easy to obtain and low in cost; the steps are simple, and the target product can be prepared by only two steps; the operation is simple and easy for industrial operation; reaction conditions are mild and easy to realize; less wastewater is generated, and the method is green, safe and environment-friendly; and the related raw materials and intermediate products are stable, the reaction selectivity is high, byproducts are few, the yield and purity of the target product are high, and the method is suitable for industrial production.
Deoxofluorination of (Hetero)aromatic Acids
Alekseenko, Anatoliy N.,Bugera, Maksym Ya.,Gerus, Igor I.,Kiriakov, Oleksandr,Klipkov, Anton A.,Mykhailiuk, Pavel K.,Pustovit, Yurii,Razhyk, Bohdan,Semenov, Sergey,Starova, Viktoriia S.,Tananaiko, Oksana Yu.,Tarasenko, Karen,Tolmachev, Andrei A.,Trofymchuk, Serhii,Zaporozhets, Olga A.
, p. 3110 - 3124 (2020/03/23)
Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.
Method for preparing 2-hydroxy-6-trifluoromethyl pyridine
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Paragraph 0017, (2018/03/23)
The invention relates to the technical field of chemical synthesis, and particularly discloses a method for preparing 2-hydroxy-6-trifluoromethyl pyridine. The method for preparing the 2-hydroxy-6-trifluoromethyl pyridine is characterized in that 2-chloro-6-trifluoromethyl pyridine as a raw material is mixed with a potassium hydroxide water solution for sealed reaction; after the reaction is completed, a hydrochloric acid solution is added dropwise to the reaction material for neutralization, and a product is obtained by centrifugation, washing with water, secondary centrifugation, and drying.The raw material is simple and easy to obtain, no organic solvent is added in the reaction process, the process is simple, the production cost is low, the product yield is high, and the method is suitable for wide promotion and application.