910132-85-3

Basic information

• Product Name: methyl (E)-4-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)-3,5-dimethylbenzoate
• Synonyms: methyl (E)-4-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)-3,5-dimethylbenzoate
• CAS NO: 910132-85-3
• Molecular Weight: 290.359
• Mol File: 910132-85-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (E)-4-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)-3,5-dimethylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (E)-4-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)-3,5-dimethylbenzoate(910132-85-3)
• EPA Substance Registry System: methyl (E)-4-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)-3,5-dimethylbenzoate(910132-85-3)

Safety Data

• Hazardous Substances Data: 910132-85-3(Hazardous Substances Data)

Upstream product

• 1663-39-4 tert-Butyl acrylate 
• 5471-81-8 methyl 4-iodo-3-methylbenzoate 
• 80-48-8 methyl p-toluene sulfonate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 619-44-3 methyl 4-iodobenzoate 
• 341006-48-2 methyl 3,5-dimethyl-4-{[(trifluoromethyl)sulfonyl]oxy}benzoate 
• 34137-14-9 methyl 4-hydroxy-3,5-dimethylbenzoate 
• 4919-37-3 3,5-dimethyl-4-hydroxybenzoic acid 
• 10570-67-9 4-iodo-2,6-dimethylphenol 
• 576-26-1 2.6-dimethylphenol 

Downstream Products

• 910132-87-5 tert-butyl 3-(2,6-dimethyl-4-carbamoylphenyl)propanoate 
• 910132-88-6 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid 
• 910132-86-4 tert-butyl (E)-3-(2,6-dimethyl-4-carbamoylphenyl)acrylate 

Relevant articles and documents

Modular Dual-Tasked C-H Methylation via the Catellani Strategy

We report a dual-tasked methylation that is based on cooperative palladium/norbornene catalysis. Readily available (hetero)aryl halides (39 iodides and 4 bromides) and inexpensive MeOTs or trimethylphosphate are utilized as the substrates and methylating reagent, respectively. Six types of "ipso" terminations can modularly couple with this "ortho" C-H methylation to constitute a versatile methylation toolbox for preparing diversified methylated arenes. This toolbox features inexpensive methyl sources, excellent functional-group tolerance, simple reaction procedures, and scalability. Importantly, it can be uneventfully extended to isotope-labeled methylation by switching to the corresponding reagents CD3OTs or 13CH3OTs. Moreover, this toolbox can be applied to late-stage modification of biorelevant substrates with complete stereoretention. We believe these salient and practical features of our dual-tasked methylation toolbox will be welcomed by academic and industrial researchers.