910132-86-4

Basic information

• Product Name: tert-butyl (E)-3-(2,6-dimethyl-4-carbamoylphenyl)acrylate
• Synonyms: tert-butyl (E)-3-(2,6-dimethyl-4-carbamoylphenyl)acrylate
• CAS NO: 910132-86-4
• Molecular Weight: 275.348
• Mol File: 910132-86-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (E)-3-(2,6-dimethyl-4-carbamoylphenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (E)-3-(2,6-dimethyl-4-carbamoylphenyl)acrylate(910132-86-4)
• EPA Substance Registry System: tert-butyl (E)-3-(2,6-dimethyl-4-carbamoylphenyl)acrylate(910132-86-4)

Safety Data

• Hazardous Substances Data: 910132-86-4(Hazardous Substances Data)

Upstream product

• 34137-14-9 methyl 4-hydroxy-3,5-dimethylbenzoate 
• 4919-37-3 3,5-dimethyl-4-hydroxybenzoic acid 
• 10570-67-9 4-iodo-2,6-dimethylphenol 
• 576-26-1 2.6-dimethylphenol 
• 341006-48-2 methyl 3,5-dimethyl-4-{[(trifluoromethyl)sulfonyl]oxy}benzoate 
• 910132-85-3 methyl (E)-4-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)-3,5-dimethylbenzoate 

Downstream Products

• 910132-87-5 tert-butyl 3-(2,6-dimethyl-4-carbamoylphenyl)propanoate 

Relevant articles and documents

Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opioid antagonists

3-(2,6-Dimethyl-4-carbamoylphenyl)propanoic acid (Dcp), a 2′,6′-dimethyltyrosine analogue containing a carbamoyl group in place of the hydroxyl function and lacking the amino group, was synthesized. The replacement of Tyr1 in an enkephalin analogue and in dynorphin A(1-11)-NH2 with Dcp resulted in the first opioid peptide-derived antagonists that do not contain a phenolic hydroxyl group at the 1-position residue. The cyclic peptide Dcp-c[D-Cys-Gly-Phe(pNO2)-D-Cys]NH 2 represents a novel, potent μ opioid antagonist.