Regular articleEffect of long-term treatment with Rasagiline (cas 136236-51-6) on cognitive deficits and related molecular cascades in aged mice
-
Add time:09/07/2019 Source:sciencedirect.com
The present study aimed to investigate the protective effects of prolonged treatment with the selective, irreversible monoamine oxidase-B inhibitor, novel anti-parkinsonian drug, Rasagiline (cas 136236-51-6) (Azilect) in aged animals. Our findings from behavioral experiments demonstrated that long-term treatment of aged mice with rasagiline (0.2 mg/kg) exerted significant beneficial effects on mood-related dysfunction and spatial learning and memory functions. At this dose of rasagiline, chronic drug administration significantly inhibited monoamine oxidase-B activity and caused an increase in striatal dopamine and serotonin levels, while decreasing their metabolism. In addition, rasagiline treatment elevated striatal mRNA expression levels of dopamine receptors D1 and D2. Furthermore, we found that rasagiline upregulated expression levels of the synaptic plasticity markers brain-derived neurotrophic factor, tyrosine kinase-B receptor, and synapsin-1, increased Bcl-2 to Bax antiapoptotic ratio and the activity of the antioxidant enzyme, catalase in brain of aged mice. The present study demonstrated that long-term treatment with rasagiline could affect behavioral deficits in aged mice and upregulate various neuroprotective parameters in the aging brain, indicating that the drug may have therapeutic potential for treatment of age-associated neurodegenerative disorders.
We also recommend Trading Suppliers and Manufacturers of Rasagiline (cas 136236-51-6). Pls Click Website Link as below: cas 136236-51-6 suppliers
Prev:Research ReportRasagiline (cas 136236-51-6) prevents neurodegeneration in thiamine deficient rats—A longitudinal MRI study
Next:Synthesis and crystal structure of 4-amino-3-fluorophenylboronic acid) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Research ReportRasagiline (cas 136236-51-6) prevents neurodegeneration in thiamine deficient rats—A longitudinal MRI study09/06/2019
- Rasagiline (cas 136236-51-6) in Parkinson's Disease09/05/2019
- Short communicationSimultaneous bioanalysis of Rasagiline (cas 136236-51-6) and its major metabolites in human plasma by LC–MS/MS: Application to a clinical pharmacokinetic study09/04/2019
- Protective effect of Rasagiline (cas 136236-51-6) in aminoglycoside ototoxicity09/03/2019
- Chemoenzymatic synthesis of Rasagiline (cas 136236-51-6) mesylate using lipases09/02/2019
- Original research articleEssential difference between the pharmacological spectrum of (−)-deprenyl and Rasagiline (cas 136236-51-6)09/01/2019
- Case ReportRasagiline (cas 136236-51-6) induced hypersexuality in Parkinson’s disease08/31/2019
- Data articleSynthesis and characterization of 1-pyrindane derivatives as Rasagiline (cas 136236-51-6) analogues08/30/2019
- Rasagiline (cas 136236-51-6) monotherapy in early Parkinson's disease: A phase 3, randomized study in Japan08/29/2019