(S)-10-Hydroxycamptothecin (19685-09-7),(S)-10-Hydroxycamptothecin (19685-09-7) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
(S)-10-Hydroxycamptothecin
CAS No.:
19685-09-7
Deleted CAS:
104155-90-0|157405-42-0
Molecular Structure:
Formula:
C₂₀H₁₆N₂O₅
Molecular Weight:
364.35
Synonyms:
10-Hydroxy-CPT;Camptothecin, hydroxy-;1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, hydrate, (S)-;(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;Camptothecine, 10-hydroxy- (8CI);Hydroxycamptothecine;1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione-,4-ethyl-4,9-dihydroxy-, (S)- (9CI);
Density:
1.6 g/cm³
Melting Point:
265-270 °C
Boiling Point:
820.7 °C at 760 mmHg
Flash Point:
450.1 °C
Appearance:
Yellow solid
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety Description:
26-36 Details

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Chemistry

Product Name: 10-Hydroxycamptothecin
Molecular Weight: 364.35144 [g/mol]
Molecular Formula: C₂₀H₁₆N₂O₅
XLogP3-AA: 0.6
H-Bond Donor: 2
H-Bond Acceptor: 6
Index of Refraction: 1.776
Molar Refractivity: 94.97 cm³
Molar Volume: 227 cm³
Surface Tension: 92.4 dyne/cm
Density: 1.6 g/cm³
Flash Point: 450.1 °C
Enthalpy of Vaporization: 125.05 kJ/mol
Boiling Point: 820.7 °C at 760 mmHg
Vapour Pressure: 1.67E-28 mmHg at 25 °C
Appearance: Yellow Solid
Melting Point: 265-270 °C
Classification Code of (S)-10-Hydroxycamptothecin (CAS NO.19685-09-7): Drug / Therapeutic Agent; Mutation data; Natural Product
Product Categories: Alkaloids; INTERMEDIATESOFIRINOTECANHCLTRIHYDRATE; Camptothecin series; Natural Plant Extract; Chiral Reagents; Intermediates & Fine Chemicals; Pharmaceuticals; Natural Anti-cancer Medical Materials and It's Derivatives

Uses

(S)-10-Hydroxycamptothecin (CAS NO.19685-09-7) is used in the treatment of cancer. It is used to synthesis 7-Ethyl-10-Hydroxy-CPT,SN-38 .

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	104mg/kg (104mg/kg)		Drugs of the Future. Vol. 7, Pg. 629, 1982.
rat	LD	intravenous	> 10mg/kg (10mg/kg)	KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED KIDNEY, URETER, AND BLADDER: HEMATURIA	Cancer Chemotherapy and Pharmacology. Vol. 41, Pg. 257, 1998.

Safety Profile

Safety Information of (S)-10-Hydroxycamptothecin (CAS NO.19685-09-7):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
WGK Germany:3

Specification

(S)-10-Hydroxycamptothecin (CAS NO.19685-09-7), its Synonyms are (S)-10-Hydroxycamptothecin hydrate ; 10-Hydroxycamptothecin ; 10-Hydroxycamptothecine ; Camptothecin, 10-hydroxy- ; Camptothecin, hydroxy- ; Hydroxycamptothecin ; Hydroxycamptothecine ; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, hydrate, (S)- ; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione-,4-ethyl-4,9-dihydroxy-, (S)- (9CI) ; Camptothecine, 10-hydroxy- (8CI) .