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1-(2,3-Dichlorophenyl)-piperazine
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Name

1-(2,3-Dichlorophenyl)-piperazine

 EINECS N/A
CAS No. 41202-77-1 Density 1.272 g/cm3
PSA 15.27000 LogP 2.79680
Solubility N/A Melting Point 242-244ºC
Formula C10H12Cl2N2 Boiling Point 365.1 °C at 760 mmHg
Molecular Weight 231.125 Flash Point 174.6 °C
Transport Information N/A Appearance Brown Oil
Safety Risk Codes R36/37/38
Molecular Structure Molecular Structure of 41202-77-1 (1-(2,3-Dichlorophenyl)-piperazine hydrochloride) Hazard Symbols R36/37/38:;
Synonyms

4-(2,3-Dichlorophenyl)piperazine;DCPP;N-(2,3-Dichlorophenyl)piperazine;Piperazine,1-(2,3-dichlorophenyl)-;

Article Data 12

1-(2,3-Dichlorophenyl)-piperazine Synthetic route

608-27-5

2,3-dichloroaniline

334-22-5

N,N-bis(chloro-2-ethyl)amine

41202-77-1

1-(2,3-dichlorophenyl)piperazine

Conditions
ConditionsYield
Stage #1: 2,3-dichloroaniline; N,N-bis(chloro-2-ethyl)amine With tetrabutylammomium bromide; toluene-4-sulfonic acid In 5,5-dimethyl-1,3-cyclohexadiene for 48h;
Stage #2: With ammonium hydroxide pH=6 - 7;		88%
110-85-0

piperazine

56961-77-4

1-bromo-2,3-dichlorobenzene

A

41202-77-1

1-(2,3-dichlorophenyl)piperazine

B

1,1'-(2-chloro-1,3-phenylene)bispiperazine

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium (0); (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate In toluene for 18h; Heating;A 62%
B 7%
110-85-0

piperazine

87-61-6

1,2,3-trichlorobenzene

41202-77-1

1-(2,3-dichlorophenyl)piperazine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl; sodium t-butanolate In 1,4-dioxane at 100℃; for 0.166667h;37%
608-27-5

2,3-dichloroaniline

111-42-2

2,2'-iminobis[ethanol]

41202-77-1

1-(2,3-dichlorophenyl)piperazine

Conditions
ConditionsYield
With phosphorus pentoxide; triethylamine hydrochloride at 220℃; for 4h;31%
With phosphorus pentaoxide; triethylamine hydrochloride at 200℃; for 3h;21%
Stage #1: 2,3-dichloroaniline; 2,2'-iminobis[ethanol] With phosphorus pentoxide; triethylamine hydrochloride at 220℃; for 4h; Inert atmosphere;
Stage #2: With sodium hydroxide In water at 0℃; pH=10;		15%
110-85-0

piperazine

56961-77-4

1-bromo-2,3-dichlorobenzene

41202-77-1

1-(2,3-dichlorophenyl)piperazine

Conditions
ConditionsYield
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0) In toluene at 60 - 70℃; Buchwald amination;

1-(2,3-dichlorophenyl)-piperazine hydrochloride

41202-77-1

1-(2,3-dichlorophenyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane; water for 0.5h;

C21H32BClN2O4

41202-77-1

1-(2,3-dichlorophenyl)piperazine

Conditions
ConditionsYield
With copper dichloride In methanol; water at 80℃;
821-48-7

bis-(2-chloroethyl)amine hydrochloride

608-27-5

2,3-dichloroaniline

41202-77-1

1-(2,3-dichlorophenyl)piperazine

Conditions
ConditionsYield
With potassium iodide at 150℃; Inert atmosphere;
76911-01-8

5-hexynyl p-toluenesulfonate

41202-77-1

1-(2,3-dichlorophenyl)piperazine

1-(2,3-dichlorophenyl)-4-(hex-5-yn-1-yl)piperazine

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In acetone for 12h; Reflux;98%
41202-77-1

1-(2,3-dichlorophenyl)piperazine

194719-57-8

2-(6-bromohexyl)–2H-naphtho[1,8-cd]isothiazole1,1-dioxide

2-{6-[4-(2,3-dichlorophenyl)piperazin-1-yl]hexyl}-(2H)naphtho[1,8-cd][1,2]thiazole-1,1(2H)-dione hydrochloride

Conditions
ConditionsYield
Stage #1: 1-(2,3-dichlorophenyl)piperazine; 2-(6-bromohexyl)–2H-naphtho[1,8-cd]isothiazole1,1-dioxide With tetrabutylammomium bromide; potassium carbonate; sodium hydroxide In acetonitrile for 0.0138889h; Microwave irradiation;
Stage #2: With hydrogenchloride In 1,4-dioxane; acetone		98%

1-(2,3-Dichlorophenyl)-piperazine Chemical Properties

Molecular Structure of 1-(2,3-Dichlorophenyl)-piperazine hydrochloride (CAS NO.41202-77-1):

IUPAC Name: 1-(2,3-dichlorophenyl)piperazin-4-ium 
Empirical Formula: C10H13Cl3N2
Molecular Weight: 267.5826
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 3.24 Å2
Density: 1.272 g/cm3
Flash Point: 174.6 °C
Enthalpy of Vaporization: 61.14 kJ/mol
Boiling Point: 365.1 °C at 760 mmHg
Vapour Pressure: 1.6E-05 mmHg at 25 °C
Melting point: 242-244 °C
Product Categories: pharmacetical; PiperazineDerivative; Piperazine derivates; API intermediates; Aromatics Compounds; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals; Aripiprazole; piperazines

1-(2,3-Dichlorophenyl)-piperazine Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note: Irritant

1-(2,3-Dichlorophenyl)-piperazine Specification

  1-(2,3-Dichlorophenyl)-piperazine hydrochloride , with CAS number of 41202-77-1, can be called 1-(2,3-Dichlorophenyl)piperazine hydrochloride (1:1) ; 1-(2,3-Dichlorphenyl)piperazinhydrochlorid ; piperazine, 1-(2,3-dichlorophenyl)-, hydrochloride (1:1) ; 1-(2,3-Dichlorophenyl)-Piperazine HCl . It is a kind of brown oil.

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