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Name	2,4-Dimethylthiazole-5-carboxylic acid	EINECS	N/A
CAS No.	53137-27-2	Density	1.341 g/cm³
PSA	78.43000	LogP	1.45810
Solubility	N/A	Melting Point	235 °C (dec.)
Formula	C₆H₇NO₂S	Boiling Point	306.158 °C at 760 mmHg
Molecular Weight	157.193	Flash Point	138.96 °C
Transport Information	N/A	Appearance	N/A
Safety	22-24/25-37/39-26	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	2,4-Dimethyl-1,3-thiazole-5-carboxylicacid;5-Carboxy-2,4-dimethylthiazole;RU 21542;	Article Data	7

2,4-Dimethylthiazole-5-carboxylic acid Synthetic route

: 7210-77-7
ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate

: 53137-27-2
2,4-dimethyl-thiazole-5-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water for 4h; Reflux;	90%
With potassium hydroxide
With potassium hydroxide In methanol; water

: 28599-52-2
5-bromo-2,4-dimethyl-1,3-thiazole

: 53137-27-2
2,4-dimethyl-thiazole-5-carboxylic acid

Conditions

Conditions	Yield
With ethanol; phenyllithium Behandeln des Reaktionsgemisches mit CO2;

: 7210-77-7
ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate

A: 53137-27-2
2,4-dimethyl-thiazole-5-carboxylic acid

B: 66806-33-5
2,4-dimethyl-thiazole-5-carboxylic acid amide

Conditions

Conditions	Yield
With ammonia

: 2,4-dimethyl-thiazole-5-carboxylic acid methyl ester; hydrochloride

: 53137-27-2
2,4-dimethyl-thiazole-5-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide at 20℃; Hydrolysis;

: 53137-27-2
2,4-dimethyl-thiazole-5-carboxylic acid

: 75-65-0
tert-butyl alcohol

: tert-butyl (2,4-dimethylthiazol-5-yl)carbamate

Conditions

Conditions	Yield
With triethanolamine; diphenyl phosphoryl azide at 85℃; for 3h; Inert atmosphere;	96.5%
With diphenyl phosphoryl azide; triethylamine at 85℃; for 4h;	88.54%

: 123-91-1
1,4-dioxane

: 53137-27-2
2,4-dimethyl-thiazole-5-carboxylic acid

: 1597710-80-9
1,4-dioxan-2-yl 2,4-dimethylthiazole-5-carboxylate

Conditions

Conditions	Yield
With iron(III)-acetylacetonate; di-tert-butyl peroxide at 120℃; for 24h; Schlenk technique;	94%

: 53137-27-2
2,4-dimethyl-thiazole-5-carboxylic acid

: 591-50-4
iodobenzene

: 19968-55-9
2,4-dimethyl-5-phenylthiazole

Conditions

Conditions	Yield
With silver (II) carbonate; triphenylphosphine; palladium dichloride In N,N-dimethyl acetamide; toluene at 135℃; for 16h; Sealed tube;	93%

: 53137-27-2
2,4-dimethyl-thiazole-5-carboxylic acid

: 1227469-85-3
potassium 2,4-dimethyl-1,3-thiazole-5-carboxylate

Conditions

Conditions	Yield
With potassium tert-butylate In ethanol at 20℃; for 3h; Inert atmosphere;	89%

: 53137-27-2
2,4-dimethyl-thiazole-5-carboxylic acid

: 1-(4-methoxyphenyl)-3-methylpiperazin-2-one hydrochloride

: C18H21N3O3S

Conditions

Conditions	Yield
Stage #1: 2,4-dimethyl-thiazole-5-carboxylic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; Stage #2: 1-(4-methoxyphenyl)-3-methylpiperazin-2-one hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h; Cooling with ice;	88%

: 53137-27-2
2,4-dimethyl-thiazole-5-carboxylic acid

: 6-(2-aminooxazol-4-yl)-3,4-dihydroquinolin-2(1H)-one

: 2,4-dimethyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)oxazol-2-yl)thiazole-5-carboxamide

Conditions

Conditions	Yield
With pyridine; propylphosphonic anhydride In ethyl acetate; acetonitrile at 50℃; for 120h; Sealed tube;	87%

2,4-Dimethylthiazole-5-carboxylic acid Chemical Properties

IUPAC Name: 2,4-Dimethyl-1,3-thiazole-5-carboxylic acid
Systematic of 5-Thiazolecarboxylicacid, 2,4-dimethyl- (CAS NO.53137-27-2): Timtec-bb sbb005433 ; Rarechem al be 1354 ; Akos bbs-00004449 ; Akos bb-8977 ; 2,4-Dimethyl-1,3-thiazole-5-carboxylic acid ; 2,4-Dimethyl-5-thiazolecarboxylic acid ; 2,4-Dimethylthiazole-5-carboxylic acid ; Iflab-bb f1912-0028
CAS NO: 53137-27-2
Molecular Formula of 5-Thiazolecarboxylicacid, 2,4-dimethyl- (CAS NO.53137-27-2): C₆H₇NO₂S
Molecular Weight: 157.1903
Molecular Structure:

Melting Point: 235 °C
ProductCategories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts ; Building Blocks ; Heterocyclic Building Blocks ; Thiazoles
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 67.43 Å²
Index of Refraction: 1.585
Molar Refractivity: 39.3 cm³
Molar Volume: 117.2 cm³
Surface Tension: 56.9 dyne/cm
Density of 5-Thiazolecarboxylicacid, 2,4-dimethyl- (CAS NO.53137-27-2): 1.341 g/cm³
Flash Point: 139 °C
Enthalpy of Vaporization: 57.72 kJ/mol
Boiling Point: 306.2 °C at 760 mmHg
Vapour Pressure: 0.000342 mmHg at 25°C

2,4-Dimethylthiazole-5-carboxylic acid Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-37/39-26
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
S37/39: Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT

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