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Name	2-Chloro-5-hydroxypyridine	EINECS	670-289-1
CAS No.	41288-96-4	Density	1.392 g/cm³
PSA	33.12000	LogP	1.44060
Solubility	N/A	Melting Point	155-158 °C
Formula	C₅H₄ClNO	Boiling Point	351.9 °C at 760 mmHg
Molecular Weight	129.546	Flash Point	166.6 °C
Transport Information	N/A	Appearance	Light yellow cryst
Safety	26-36/37/39-36	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	T, Xi
Synonyms	6-Chloro-3-pyridinol;6-chloropyridin-3-ol;	Article Data	20

2-Chloro-5-hydroxypyridine Synthetic route

: 188057-24-1
5-Acetoxy-2-chloropyridine

: 41288-96-4
6-chloropyridine-3-ol

Conditions

Conditions	Yield
With potassium carbonate In methanol at 20℃; for 2h;	96%
With hydrogenchloride; potassium carbonate In methanol	96%
With potassium carbonate In methanol at 20℃;	94%

: 1235099-38-3
potassium (6-chloropyridin-3-yl)trifluoroborate

: 41288-96-4
6-chloropyridine-3-ol

Conditions

Conditions	Yield
With Oxone; water In acetone at 20℃; for 0.0833333h;	91%

: 444120-91-6
6-chloropyridin-3-ylboronic acid

: 41288-96-4
6-chloropyridine-3-ol

Conditions

Conditions	Yield
With dihydrogen peroxide In dichloromethane; water at 20℃; for 20h;	82%

: 53939-30-3
5-bromo-2-chloropyridine

: 41288-96-4
6-chloropyridine-3-ol

Conditions

Conditions	Yield
With N1,N2-bis(thiophen-2-ylmethyl)oxalamide; caesium carbonate; copper(I) bromide; sodium hydroxide In water; dimethyl sulfoxide at 85℃; for 20h; Reagent/catalyst; Temperature; Glovebox; Schlenk technique; Sealed tube; Inert atmosphere; chemoselective reaction;	56%

: 5350-93-6
6-Chloro-pyridin-3-ylamine

: 41288-96-4
6-chloropyridine-3-ol

Conditions

Conditions	Yield
Stage #1: 6-Chloro-pyridin-3-ylamine With sulfuric acid; sodium nitrite at 5 - 20℃; for 0.5h; Stage #2: With acetic acid at 100℃;	54%
With sulfuric acid; sodium nitrite Yield given;
Multi-step reaction with 2 steps 1: 1.) t-BuONO, BF3*OEt2 / 1.) CH2Cl2, DME, 2.) heating 2: K2CO3 / methanol View Scheme
Multi-step reaction with 2 steps 1: diethyl ether; ethanol; acetic anhydride 2: acetic acid / aqueous KOH View Scheme

: C11H12(2)HClOS

: 444120-94-9
2-chloro-5-(4,4, 5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

A: 41288-96-4
6-chloropyridine-3-ol

B: (4R,5R)-4,5-[2H]2-5-(2-chloropyrid-5-yl)octa-1,7-dien-4-ol

C: C9H9(2)HClN

D: C9H9(2)HClNO

E: 1693-83-0
1-Methyl-4-((R)-2-methyl-propane-2-sulfinyl)-benzene

Conditions

Conditions	Yield
Stage #1: C11H12(2)HClOS; 2-chloro-5-(4,4, 5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine With phenyllithium In tetrahydrofuran at -78 - 20℃; for 3h; Inert atmosphere; Stage #2: With sodium hydroxide In tetrahydrofuran; water at 0℃; for 1.5h;	A n/a B 16% C 28% D n/a E 7%

...Expand

: C7H9BClNO2

: 41288-96-4
6-chloropyridine-3-ol

Conditions

Conditions	Yield
With dihydrogen peroxide In tetrahydrofuran; cyclohexane; acetic acid at 20℃; for 0.5h; Oxidation;

: 109-09-1
2-chloropyridine

A: 41288-96-4
6-chloropyridine-3-ol

B: 6636-78-8
2-chloro-3-hydroxypyridine

Conditions

Conditions	Yield
With dihydrogen peroxide; copper(II) nitrate In phosphate buffer; acetonitrile at 50℃; for 5h;

: 444120-94-9
2-chloro-5-(4,4, 5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 41288-96-4
6-chloropyridine-3-ol

Conditions

Conditions	Yield
With dihydrogen peroxide In dichloromethane; water at 20℃; for 20h;

: 5350-93-6
6-Chloro-pyridin-3-ylamine

A: 41288-96-4
6-chloropyridine-3-ol

B (S)-BocNHCH(C2H5)CH2OH or (S)-BocNHCH(C2H5)CH2OTs: (S)-BocNHCH(C2H5)CH2OH or (S)-BocNHCH(C2H5)CH2OTs

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: BF3*Et2O; i-BuONO / 1,2-dimethoxy-ethane; CH2Cl2 / 0 °C 1.2: 62 percent / 75 °C 2.1: 94 percent / K2CO3 / methanol / 20 °C View Scheme

2-Chloro-5-hydroxypyridine Chemical Properties

Empirical Formula: C₅H₄ClNO
Molecular Weight: 129.5444
Nominal Mass: 129 Da
Average Mass: 129.5444 Da
Monoisotopic Mass: 128.998141 Da
Index of Refraction: 1.583
Molar Refractivity: 31.12 cm³
Molar Volume: 93 cm³
Surface Tension: 54 dyne/cm
Density: 1.392 g/cm³
Flash Point: 166.6 °C
Enthalpy of Vaporization: 62.02 kJ/mol
Boiling Point: 351.9 °C at 760 mmHg
Vapour Pressure: 1.97E-05 mmHg at 25 °C
Melting Point: 155-158 °C
Appearance: Light yellow cryst
Structure of 2-Chloro-5-hydroxypyridine (CAS NO.41288-96-4):

IUPAC Name: 6-Chloropyridin-3-ol
Canonical SMILES: C1=CC(=NC=C1O)Cl
InChI: InChI=1S/C5H4ClNO/c6-5-2-1-4(8)3-7-5/h1-3,8H
InChIKey: KVCOOWROABTXDJ-UHFFFAOYSA-N
Product Category of 2-Chloro-5-hydroxypyridine (CAS NO.41288-96-4): pyridine derivative;Pyridine Series;Halides;Boronic Acid

2-Chloro-5-hydroxypyridine Uses

2-Chloro-5-hydroxypyridine (CAS NO.41288-96-4) is mainly used as chemical intermediate in medical and industry.

2-Chloro-5-hydroxypyridine Safety Profile

Hazard Codes: Toxic T, Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

2-Chloro-5-hydroxypyridine Specification

2-Chloro-5-hydroxypyridine , its cas register number is 41288-96-4. It also can be called 2-Chloro-5-pyridinol ; 6-Chloropyridin-3-ol ; and 6-Chloro-3-pyridinol .

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