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CAS No.: | 41288-96-4 |
---|---|
Name: | 2-Chloro-5-hydroxypyridine |
Article Data: | 20 |
Molecular Structure: | |
Formula: | C5H4ClNO |
Molecular Weight: | 129.546 |
Synonyms: | 6-Chloro-3-pyridinol;6-chloropyridin-3-ol; |
EINECS: | 670-289-1 |
Density: | 1.392 g/cm3 |
Melting Point: | 155-158 °C |
Boiling Point: | 351.9 °C at 760 mmHg |
Flash Point: | 166.6 °C |
Appearance: | Light yellow cryst |
Hazard Symbols: | T, Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36/37/39-36 |
PSA: | 33.12000 |
LogP: | 1.44060 |
5-Acetoxy-2-chloropyridine
6-chloropyridine-3-ol
Conditions | Yield |
---|---|
With potassium carbonate In methanol at 20℃; for 2h; | 96% |
With hydrogenchloride; potassium carbonate In methanol | 96% |
With potassium carbonate In methanol at 20℃; | 94% |
potassium (6-chloropyridin-3-yl)trifluoroborate
6-chloropyridine-3-ol
Conditions | Yield |
---|---|
With Oxone; water In acetone at 20℃; for 0.0833333h; | 91% |
6-chloropyridin-3-ylboronic acid
6-chloropyridine-3-ol
Conditions | Yield |
---|---|
With dihydrogen peroxide In dichloromethane; water at 20℃; for 20h; | 82% |
5-bromo-2-chloropyridine
6-chloropyridine-3-ol
Conditions | Yield |
---|---|
With N1,N2-bis(thiophen-2-ylmethyl)oxalamide; caesium carbonate; copper(I) bromide; sodium hydroxide In water; dimethyl sulfoxide at 85℃; for 20h; Reagent/catalyst; Temperature; Glovebox; Schlenk technique; Sealed tube; Inert atmosphere; chemoselective reaction; | 56% |
6-Chloro-pyridin-3-ylamine
6-chloropyridine-3-ol
Conditions | Yield |
---|---|
Stage #1: 6-Chloro-pyridin-3-ylamine With sulfuric acid; sodium nitrite at 5 - 20℃; for 0.5h; Stage #2: With acetic acid at 100℃; | 54% |
With sulfuric acid; sodium nitrite Yield given; | |
Multi-step reaction with 2 steps 1: 1.) t-BuONO, BF3*OEt2 / 1.) CH2Cl2, DME, 2.) heating 2: K2CO3 / methanol View Scheme | |
Multi-step reaction with 2 steps 1: diethyl ether; ethanol; acetic anhydride 2: acetic acid / aqueous KOH View Scheme |
2-chloro-5-(4,4, 5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
A
6-chloropyridine-3-ol
E
1-Methyl-4-((R)-2-methyl-propane-2-sulfinyl)-benzene
Conditions | Yield |
---|---|
Stage #1: C11H12(2)HClOS; 2-chloro-5-(4,4, 5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine With phenyllithium In tetrahydrofuran at -78 - 20℃; for 3h; Inert atmosphere; Stage #2: With sodium hydroxide In tetrahydrofuran; water at 0℃; for 1.5h; | A n/a B 16% C 28% D n/a E 7% |
6-chloropyridine-3-ol
Conditions | Yield |
---|---|
With dihydrogen peroxide In tetrahydrofuran; cyclohexane; acetic acid at 20℃; for 0.5h; Oxidation; |
Conditions | Yield |
---|---|
With dihydrogen peroxide; copper(II) nitrate In phosphate buffer; acetonitrile at 50℃; for 5h; |
2-chloro-5-(4,4, 5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
6-chloropyridine-3-ol
Conditions | Yield |
---|---|
With dihydrogen peroxide In dichloromethane; water at 20℃; for 20h; |
6-Chloro-pyridin-3-ylamine
A
6-chloropyridine-3-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: BF3*Et2O; i-BuONO / 1,2-dimethoxy-ethane; CH2Cl2 / 0 °C 1.2: 62 percent / 75 °C 2.1: 94 percent / K2CO3 / methanol / 20 °C View Scheme |
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Empirical Formula: C5H4ClNO
Molecular Weight: 129.5444
Nominal Mass: 129 Da
Average Mass: 129.5444 Da
Monoisotopic Mass: 128.998141 Da
Index of Refraction: 1.583
Molar Refractivity: 31.12 cm3
Molar Volume: 93 cm3
Surface Tension: 54 dyne/cm
Density: 1.392 g/cm3
Flash Point: 166.6 °C
Enthalpy of Vaporization: 62.02 kJ/mol
Boiling Point: 351.9 °C at 760 mmHg
Vapour Pressure: 1.97E-05 mmHg at 25 °C
Melting Point: 155-158 °C
Appearance: Light yellow cryst
Structure of 2-Chloro-5-hydroxypyridine (CAS NO.41288-96-4):
IUPAC Name: 6-Chloropyridin-3-ol
Canonical SMILES: C1=CC(=NC=C1O)Cl
InChI: InChI=1S/C5H4ClNO/c6-5-2-1-4(8)3-7-5/h1-3,8H
InChIKey: KVCOOWROABTXDJ-UHFFFAOYSA-N
Product Category of 2-Chloro-5-hydroxypyridine (CAS NO.41288-96-4): pyridine derivative;Pyridine Series;Halides;Boronic Acid
2-Chloro-5-hydroxypyridine (CAS NO.41288-96-4) is mainly used as chemical intermediate in medical and industry.
Hazard Codes: T,Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
2-Chloro-5-hydroxypyridine , its cas register number is 41288-96-4. It also can be called 2-Chloro-5-pyridinol ; 6-Chloropyridin-3-ol ; and 6-Chloro-3-pyridinol .